ArticleThe British journal of radiology2019
Modelling the influence of treatment time on the biological effectiveness of single radiosurgery treatments: derivation of "protective" dose modification factors.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiosurgery in recurrent and persistent Cushing's Disease: a Systematic Review and Meta-Analysis.Neurosurgical review · 2026Pooled it
- Article
- Shortened High-dose Palliative Radiotherapy for Lung Cancer (SHiP-Rt): protocol for a single-arm, multicentre, phase II study.BMJ open · 2026Article
- The Role of Biological Effective Dose in Gamma Knife Radiosurgery: A Systematic Review Across Multiple Indications.Journal of clinical medicine · 2026Review
- Gamma knife radiosurgery for cerebral cavernous malformations: biologically effective dose predicts therapeutic outcomes.Frontiers in neurology · 2025Article
- Biological effective dose as a predictor of local tumor control in stereotactic radiosurgery treated parasellar meningioma patients.Journal of neuro-oncology · 2024Article
- DSA Quantitative Analysis and Predictive Modeling of Obliteration in Cerebral AVM following Stereotactic Radiosurgery.AJNR. American journal of neuroradiology · 2024Article
- Article
- Efficacy and safety of immunoradiotherapy for advanced non-small cell lung cancer: a retrospective comparative cohort study.Journal of thoracic disease · 2023Article
- Gamma Knife Radiosurgery for Cushing's Disease: Evaluation of Biological Effective Dose from a Single-Center Experience.Journal of clinical medicine · 2023Article
- Toward semi-automatic biologically effective dose treatment plan optimisation for Gamma Knife radiosurgery.Physics in medicine and biology · 2022Article
- The Effect ofCancers · 2022Article
- Biologically effective dose correlates with linear tumour volume changes after upfront single-fraction stereotactic radiosurgery for vestibular schwannomas.Neurosurgical review · 2022Article
- Re-irradiation for intra-thoracic tumours and extra-thoracic breast cancer: dose accumulation, evaluation of efficacy and toxicity based on a literature review.The British journal of radiology · 2022Review
- Jacob I. Fabrikant Award lectureJournal of radiosurgery and SBRT · 2022Article
- Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates.Journal of radiosurgery and SBRT · 2022Article
- Biologically effective dose correlates with linear tumor volume changes after upfront single-fraction stereotactic radiosurgery for vestibular schwannomas.Neurosurgical review · 2021Article
- Tumor-dose-rate variations during robotic radiosurgery of oligo and multiple brain metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Article
- The impact of unscheduled gaps and iso-centre sequencing on the biologically effective dose in Gamma Knife radiosurgery.Journal of radiosurgery and SBRT · 2021Article
- The Impact of Insulin-Like Growth Factor Index and Biologically Effective Dose on Outcomes After Stereotactic Radiosurgery for Acromegaly: Cohort Study.Neurosurgery · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo provide simpler models for adjusting total dose to compensate for significant variations in central nervous system radiosurgical treatment times, which vary and will influence treatment bioeffectiveness. At present, no allowance is made for time variations. A framework of simpler equations would allow radiosurgical outcomes to be analysed with respect to treatment time, and a system for dose adjustments between radioisotope and linac-based techniques with different treatment durations.
methodsThe standard biological effective dose (BED) equations for fractionated and protracted radiations have been combined, using biexponential DNA repair kinetics, to provide the following equation:
resultsThe results obtained using simpler models are compared with those obtained using more complex retrospective Gamma Knife BED treatment planning by Millar et al. (2015) in a group of 23 patients on a 13 Gy physical isodose surface. The above equation provides a BED value around 3% above their minimum values, 4% below their average value and 10% below their maximum BED values. Changes in isocentre numbers used, due to treatment plan complexity, can influence total treatment time, producing variations in the BED-time data: instead of a unique curve for each "
conclusionThe models allow better analysis of radiosurgical treatment time data and guidance to the choice of dose to match the overall time. Although this study is based on Gamma Knife treatments, in principle the methods will also apply to any radiosurgical technique, so that dose-time compensations can be made between differing techniques. ADVANCES IN KNOWLEDGE: The new BED equation-based framework is relevant to analyse and optimise radiosurgical treatments.
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