Evidence map›Paper›PMID 29744805›Full record

ReviewJournal of cardiovascular translational research2018

Regenerative Therapy for Cardiomyopathies.

Zi Wang, Xuan Su, Muhammad Ashraf, Il-Man Kim, Neal L Weintraub, Meng Jiang, Yaoliang Tang

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Review
  4. hPSC gene editing for cardiac disease therapy.Pflugers Archiv : European journal of physiology · 2022
    Review
  5. Review
  6. New Developments in Exosomal lncRNAs in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. New Insights into the Role of Exosomes in the Heart After Myocardial Infarction.Journal of cardiovascular translational research · 2019
    Review
  14. Article
  15. Review
  16. Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis.Journal of cardiovascular translational research · 2018
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Zi WangDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160, Pujian Road, Shanghai, 200127, China.
Xuan SuDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160, Pujian Road, Shanghai, 200127, China.
Muhammad AshrafVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Il-Man KimVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Neal L WeintraubVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Meng JiangDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160, Pujian Road, Shanghai, 200127, China. jiangmeng0919@163.com.
Yaoliang TangVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. yaotang@augusta.edu.ORCID 0000-0002-8372-1545
Augusta University · USRenji Hospital · CN

Funding

Hypoxia and cardiac stem cell homingR01HL086555 · NHLBI · UNIVERSITY OF CINCINNATI · PI TANG, YAO LIANG · 2008 to 2019
$3.5M
Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
Beta-arrestin signaling and microRNA biogenesis in cardioprotectionR01HL124251 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, IL-MAN · 2014 to 2018
$1.9M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
American Heart Association-American Stroke Association 18TPA34170104NHLBI NIH HHS R01 HL086555NHLBI NIH HHS R01 HL124251NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NIAMS NIH HHS R01 AR070029
6 · The paper itself

Abstract

Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell therapy for heart disease has gained traction over the past two decades and is an emerging option for the treatment of myocardial dysfunction. In this review, we summarize the current literature on different types of stem cells and their potential usage in ischemic and non-ischemic heart diseases. We emphasize the clinical utility of stem cells to improve myocardial structural and function, promote microvascular angiogenesis, and diminish scar size and major adverse cardiovascular events. We also discuss the therapeutic potential of microvesicles, such as exosomes, in the treatment of CVDs, which may open novel avenues for further clinical studies.

Indexed as

RegenerationAnimalsCardiomyopathiesExosomesGenetic TherapyGenotypeHumansMyocardiumMyocytes, CardiacPhenotypeRecovery of FunctionRegenerative MedicineStem Cell TransplantationTreatment OutcomeAngiogenesisExosomesIschemic heart diseasesMicrovesiclesNon-ischemic heart diseasesStem cells

Identifiers

PMID29744805
PMCPMC6226381
OpenAlexW2801789724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.