Evidence map›Paper›PMID 29744773›Full record

ArticleNeuromolecular medicine2018

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients.

Anna Gójska-Grymajło, Maciej Zieliński, Dariusz Gąsecki, Kamil Kowalczyk, Mariusz Kwarciany, Barbara Seroczyńska, Walenty M Nyka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromolecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna Gójska-GrymajłoDepartment of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland. annagojska@gumed.edu.pl.ORCID 0000-0002-6065-3754
Maciej ZielińskiDepartment of Clinical Immunology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Dariusz GąseckiDepartment of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.
Kamil KowalczykDepartment of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.
Mariusz KwarcianyDepartment of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.
Barbara SeroczyńskaDepartment of Medical Laboratory Diagnostics and Bank of Frozen Tissues and Genetic Specimens, Medical University of Gdańsk, Gdańsk, Poland.
Walenty M NykaDepartment of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.
Gdańsk Medical University · PL

Funding

Narodowe Centrum Nauki OPUS UMO-2011/01/B/NZ5/01348Polish Ministry of Science and Higher Education MN-01-0143/08
6 · The paper itself

Abstract

Ischemic stroke causes mobilization of various groups of progenitor cells from bone marrow to bloodstream and this correlates with the neurological status of stroke patients. The goal of our study was to identify the activity of chosen progenitor/stem cells in the peripheral blood of acute ischemic stroke patients in the first 7 days after the incident, through associations between the levels of the cells and clinical features of the patients. Thirty-three acute ischemic stroke patients and 15 non-stroke control subjects had their venous blood collected repeatedly in order to assess the levels of the CD45-CD34 + CD271+, the CD45-CD34 + CXCR4+, the CD45-CD34 + CXCR7+, and the CD45-CD34 + CD133+ stem/progenitor cells by means of flow cytometry. The patients underwent repeated neurological and clinical assessments, pulse wave velocity (PWV) assessment on day 5, and MRI on day 1 and 5 ± 2. The levels of the CD45-CD34 + CXCR7+ and the CD45-CD34 + CD271+ cells were lower in the stroke patients compared with the control subjects. Only the CD45-CD34 + CD271+ cells correlated positively with lesion volume in the second MRI. The levels of the CD45-CD34 + CD133+ cells on day 2 correlated negatively with PWV and NIHSS score on day 9. The patients whose PWV was above 10 m/s had significantly higher levels of the CD45-CD34 + CXCR4+ and the CD45-CD34 + CXCR7+ cells on day 1 than those with PWV below 10 m/s. This study discovers possible activity of the CD45-CD34 + CD271+ progenitor/stem cells during the first 7 days after ischemic stroke, suggests associations of the CD45-CD34 + CD133+ cells with the neurological status of stroke patients, and some activity of the CD45-CD34 + CD133+, the CD45-CD34 + CXCR4+, and the CD45-CD34 + CXCR7+ progenitor/stem cells in the process of arterial remodeling.

Indexed as

AC133 AntigenAgedAntigens, CDAntigens, DifferentiationBlood Cell CountBrain IschemiaComorbidityFemaleFlow CytometryHumansMagnetic Resonance ImagingMaleMiddle AgedNerve Tissue ProteinsNeuroimagingReceptors, CXCRAC133 AntigenACKR3 protein, humanAntigens, CDAntigens, DifferentiationCXCR4 protein, humanNerve Tissue ProteinsNGFR protein, humanPROM1 protein, humanReceptors, CXCRReceptors, CXCR4Receptors, Nerve Growth FactorCD133CD271CXCR4CXCR7Ischemic strokeStem cells

Identifiers

PMID29744773
PMCPMC6097064
OpenAlexW2800237305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.