Evidence map›Paper›PMID 29744762›Full record

Trial reportInternational ophthalmology2019

Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson's disease.

Samir Hasanov, Elif Demirkilinc Biler, Ahmet Acarer, Cezmi Akkın, Zafer Colakoglu, Onder Uretmen

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Dynamics of retinal changes in early-stage Parkinson's disease.Acta neuropathologica communications · 2025
    Article
  7. Review
  8. Assessment of retinal blood flow changes in early Parkinson's disease: An optical coherence tomography angiography study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
  9. Review
  10. Article
  11. Structural and functional changes in the retina in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samir HasanovDepartment of Ophthalmology, Ege University Faculty of Medicine, 35040, Bornova, Izmir, Turkey.
Elif Demirkilinc BilerDepartment of Ophthalmology, Ege University Faculty of Medicine, 35040, Bornova, Izmir, Turkey. elif.dem@gmail.com.
Ahmet AcarerDepartment of Neurology, Ege University Faculty of Medicine, Izmir, Turkey.
Cezmi AkkınDepartment of Ophthalmology, Ege University Faculty of Medicine, 35040, Bornova, Izmir, Turkey.
Zafer ColakogluDepartment of Neurology, Ege University Faculty of Medicine, Izmir, Turkey.
Onder UretmenDepartment of Ophthalmology, Ege University Faculty of Medicine, 35040, Bornova, Izmir, Turkey.
Ege University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate and follow-up of functional and morphological changes of the optic nerve and ocular structures prospectively in patients with early-stage Parkinson's disease. MATERIALS AND

methodsNineteen patients with a diagnosis of early-stage Parkinson's disease and 19 age-matched healthy controls were included in the study. All participants were examined minimum three times at the intervals of at least 6 month following initial examination. Pattern visually evoked potentials (VEP), contrast sensitivity assessments at photopic conditions, color vision tests with Ishihara cards and full-field visual field tests were performed in addition to measurement of retinal nerve fiber layer (RNFL) thickness of four quadrants (top, bottom, nasal, temporal), central and mean macular thickness and macular volumes.

resultsBest corrected visual acuity was observed significantly lower in study group within all three examinations. Contrast sensitivity values of the patient group were significantly lower in all spatial frequencies. P100 wave latency of VEP was significantly longer, and amplitude was lower in patient group; however, significant deterioration was not observed during the follow-up. Although average peripapillary RNFL thickness was not significant between groups, RNFL thickness in the upper quadrant was thinner in the patient group. While there was no difference in terms of mean macular thickness and total macular volume values between the groups initially, a significant decrease occurred in the patient group during the follow-up. During the initial and follow-up process, a significant deterioration in visual field was observed in the patient group.

conclusionStructural and functional disorders shown as electro-physiologically and morphologically exist in different parts of visual pathways in early-stage Parkinson's disease.

Indexed as

AdultAgedCase-Control StudiesColor VisionContrast SensitivityEvoked Potentials, VisualFemaleFollow-Up StudiesHumansMacula LuteaMaleMiddle AgedNerve FibersOptic NerveParkinson DiseaseProspective StudiesColor visionContrast sensitivityMacular thicknessMacular volumeOCTParkinson’s diseaseRNFL thicknessVEPVisual field analysis

Identifiers

PMID29744762
OpenAlexW2801525249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.