Evidence map›Paper›PMID 29744761›Full record

ArticleInternational ophthalmology2019

Microstructural retinal regeneration after internal limiting membrane flap surgery for repair of large macular holes: a 1-year follow-up study.

Max Vieregge, Christophe Valmaggia, Hendrik P N Scholl, Josef Guber

Abstract read
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In one paragraph

Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Inverted internal limiting membrane flap technique in eyes with large idiopathic full-thickness macular hole: long-term functional and morphological outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  3. [Biomarkers in full-thickness and lamellar defects of the macula].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Review
  4. Article
  5. MANAGEMENT OF LARGE OR RECURRENT MACULAR HOLES.Current ophthalmology reports · 2020
    Article
  6. Article
  7. Internal limiting membrane flap technique in macular hole surgery.International journal of ophthalmology · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Max ViereggeEye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland.
Christophe ValmaggiaEye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland.
Hendrik P N SchollDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Josef GuberEye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, Sankt Gallen, 9007, Switzerland. josef_guber@hotmail.com.ORCID http://orcid.org/0000-0003-2681-4961
Kantonsspital St. Gallen · CHUniversity Hospital of Basel · CHUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate long-term change in functional and structural outcomes after successful repair of large macular holes (MH) with internal limiting membrane (ILM) flap techniques.

methodsEleven consecutive patients were reviewed over a 1-year time period after the successful repair of large MH with ILM flap techniques. SD-optical coherence tomography (SD-OCT) images were taken to assess the anatomical outcome after surgery, while the best-corrected visual acuity (BCVA) was tested using Snellen charts to evaluate the functional outcome. Each patient was evaluated at 1, 6 and 12 months after surgery, respectively.

resultsAll cases achieved complete anatomical closure. All patients showed a microstructural regeneration of the retina with a decrease in ellipsoid zone defects over the 1-year follow-up. Functionally, as compared to baseline, all of the patients showed improvements in best-corrected visual acuity of 1-4 lines at the final examination after 12 months post-operatively.

conclusionsLong-term results show further improvement in the best-corrected visual acuity as well as further microstructural regeneration of the retina and decrease in ellipsoid zone defects over time. The exact mechanism, which promotes closure of the macular hole and reconstruction of the ellipsoid zone after internal Limiting Membrane autograft surgery, still remains unknown.

Indexed as

AgedAged, 80 and overBasement MembraneFemaleFollow-Up StudiesHumansMaleMiddle AgedRetinaRetinal PerforationsSurgical FlapsVisual AcuityVitrectomyEllipsoid zoneFree flapInternal limiting membrane flapInverted flapMacular hole

Identifiers

PMID29744761
OpenAlexW2802505670

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.