Evidence map›Paper›PMID 29744577›Full record

ArticleInternational journal of colorectal disease2018

Incidence and risk factors of advanced neoplasia after endoscopic mucosal resection of colonic laterally spreading lesions.

Amol Agarwal, Sidyarth Garimall, Caitlin Colling, Nuzhat A Ahmad, Michael L Kochman, Gregory G Ginsberg, Vinay Chandrasekhara

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Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Amol AgarwalDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sidyarth GarimallSchool of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Caitlin CollingDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nuzhat A AhmadDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael L KochmanDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gregory G GinsbergDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vinay ChandrasekharaDivision of Gastroenterology, Mayo School of Medicine, 200 First St. SW, Rochester, MN, 55905, USA. Chandrasekhara.Vinay@mayo.edu.
University of Pennsylvania · USJohns Hopkins Medicine · USMassachusetts General Hospital · USUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate advanced neoplasia (AN) after endoscopic mucosal resection (EMR) of colonic laterally spreading lesions (LSLs).

methodsA retrospective study of patients who underwent injection-assisted EMR of colonic LSLs ≥ 10 mm was performed. Primary outcome was overall rate of AN at initial surveillance colonoscopy. Secondary outcomes were the rates of residual AN (rAN) at the EMR site and metachronous AN (mAN), and analysis of risk factors for AN, including effect of surveillance guidance.

resultsThree hundred seventy-four patients underwent successful EMR for 388 LSLs. AN occurred in 66/374 (17.6%) patients on initial surveillance colonoscopy at median follow-up of 364.5 days. Two patients had both rAN and mAN, for a total of 68 instances of AN, including 30/374 (8.0%) cases of rAN and 38/374 (10.2%) cases of mAN. On multivariate analysis, use of piecemeal resection was associated with increased likelihood of residual AN (P = 0.003, OR 9.2, 95% CI 2.1-33.3). Twenty-nine out of thirty cases (96.7%) of rAN were successfully endoscopically managed at surveillance colonoscopy.

conclusionsAN occurred in 17.6% of all patients at initial surveillance colonoscopy at a median of 1 year after EMR. Roughly half of the instances of AN were metachronous lesions. Our data support a 1-year surveillance interval after EMR of LSLs ≥ 10 mm with careful inspection of the entire colon, not just the prior resection site.

Indexed as

Colonic NeoplasmsColonoscopyNeoplasm Recurrence, LocalNeoplasm, ResidualNeoplasms, Second PrimaryAgedColonEndoscopic Mucosal ResectionFemaleHumansIncidenceIntestinal MucosaMaleMiddle AgedOutcome and Process Assessment, Health CareRetrospective StudiesAdvanced neoplasiaColonEndoscopic mucosal resectionLaterally spreading lesion

Identifiers

PMID29744577
OpenAlexW2802765616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.