Evidence map›Paper›PMID 29744562›Full record

ArticleAnalytical and bioanalytical chemistry2018

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials.

Seungkuk Ahn, Herdeline Ann M Ardoña, Johan U Lind, Feyisayo Eweje, Sean L Kim, Grant M Gonzalez, Qihan Liu, John F Zimmerman, Georgios Pyrgiotakis, Zhenyuan Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
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  11. Advances in cardiac tissue engineering and heart-on-a-chip.Journal of biomedical materials research. Part A · 2024
    Review
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  15. Article
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  19. Cardiac tissue engineering: Multiple approaches and potential applications.Frontiers in bioengineering and biotechnology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Seungkuk AhnDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Herdeline Ann M ArdoñaDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Johan U LindDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Feyisayo EwejeDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Sean L KimDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Grant M GonzalezDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Qihan LiuDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
John F ZimmermanDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.
Georgios PyrgiotakisCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Zhenyuan ZhangCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Juan Beltran-HuaracCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Paul CarpinoneCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Brij M MoudgilCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, 02138, USA.
Kevin Kit ParkerDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA. kkparker@seas.harvard.edu.

Funding

Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
Organ Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5M
Placenta-on-a-Chip for Engineered Nanomaterial Toxicity ScreeningU01ES027272 · NIEHS · HARVARD UNIVERSITY · PI PARKER, KEVIN KIT · 2016 to 2020
$2.4M
Harvard Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN) NSF Award No. 1541959Harvard University Materials Research Science and Engineering Center (MRSEC) NSF Award No. DMR-1420570National Institute of Environmental Health Sciences of the National Institutes of Health as part of the Nanotechnology Health Implications Research (NHIR) Consortium NIH Grant No. U01ES027272NIBIB NIH HHS T32 EB016652NIEHS NIH HHS U01 ES027272NIEHS NIH HHS U24 ES026946
6 · The paper itself

Abstract

Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of engineered nanomaterials (ENMs) used in consumer goods. However, several reports associate ENM exposure to negative health outcomes such as cardiovascular diseases. Therefore, understanding the pathological consequences of ENM exposure represents an important challenge, requiring model systems that can provide mechanistic insights across different levels of ENM-based toxicity. To achieve this, we developed a mussel-inspired 3D microphysiological system (MPS) to measure cardiac contractility in the presence of ENMs. While multiple cardiac MPS have been reported as alternatives to in vivo testing, most systems only partially recapitulate the native extracellular matrix (ECM) structure. Here, we show how adhesive and aligned polydopamine (PDA)/polycaprolactone (PCL) nanofiber can be used to emulate the 3D native ECM environment of the myocardium. Such nanofiber scaffolds can support the formation of anisotropic and contractile muscular tissues. By integrating these fibers in a cardiac MPS, we assessed the effects of TiO

Indexed as

BivalviaLab-On-A-Chip DevicesTissue ScaffoldsAdhesivesAnimalsCells, CulturedHeartIndolesIn Vitro TechniquesMicroscopy, Electron, ScanningMyocytes, CardiacNanofibersNanostructuresPolyestersPolymersRatsAdhesivesIndolespolycaprolactonepolydopaminePolyestersPolymersCardiotoxicityMicrophysiological systemsNanofiberNanotoxicologyPolydopamine

Identifiers

PMID29744562
PMCPMC6230313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.