Evidence map›Paper›PMID 29744553›Full record

ArticleArchivum immunologiae et therapiae experimentalis2018

Changes in MiRNA-5196 Expression as a Potential Biomarker of Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis Patients.

Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, Patryk Zarecki, Jerzy Swierkot, Piotr Gluszko, Katarzyna Bogunia-Kubik, Wlodzimierz Maslinski

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archivum immunologiae et therapiae experimentalis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marzena CiechomskaDepartment of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland. m.m.ciechomska@gmail.com.ORCID http://orcid.org/0000-0002-0961-6130
Krzysztof BonekDepartment of Rheumatology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
Michal MerdasLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Patryk ZareckiLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Jerzy SwierkotDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland.
Piotr GluszkoDepartment of Rheumatology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
Katarzyna Bogunia-KubikLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Wlodzimierz MaslinskiDepartment of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
National Institute of Geriatrics, Rheumatology and Rehabilitation · PLLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLWroclaw Medical University · PL

Funding

Foundation for Polish Science Homing Plus grant/2013-8/4National Science Centre, Poland 2015/16/S/NZ6/00041National Science Centre, Poland 2016/21/B/NZ5/01901
6 · The paper itself

Abstract

In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Disease activity of RA patients was assessed using disease activity score 28 (DAS28), whereas ankylosing spondylitis DAS (ASDAS) was used in AS patients. MiRNA-5196 expression was significantly higher in patients with RA and AS before TNF-α therapy than in those following anti-TNF-α therapy and healthy controls. Changes in miRNA-5196 expression positively correlated with delta DAS28 or delta ASDAS, respectively, following TNF-α therapy. In contrast, changes in C-reactive protein (CRP) levels in RA and AS patients did not positively correlate with DAS28 or ASDAS changes. Receiver-operating characteristic analysis showed better diagnostic accuracy of miRNA-5196 expression both in RA (area under curve (AUC) = 0.87, p = 0.055) and AS patients (AUC = 0.90, p = 0.050) compared to CRP levels in RA (AUC = 0.75, p = 0.201) and AS patients (AUC = 0.85, p = 0.086) upon biologic therapy treatment. Finding novel biomarkers, including miRNA-5196 which allow to predict and monitor anti-TNF-α response, would be of clinical value especially during the early phase of RA or AS development.

Indexed as

AdultAgedAntibodies, MonoclonalAntirheumatic AgentsArthritis, RheumatoidBiomarkersC-Reactive ProteinFemaleGene Expression RegulationHumansMaleMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionSpondylitis, AnkylosingTumor Necrosis Factor-alphaAntibodies, MonoclonalAntirheumatic AgentsBiomarkersC-Reactive ProteinMicroRNAsMIRN5196 microRNA, humanTumor Necrosis Factor-alphaAnkylosing spondylitisAnti-TNF-αBiologic therapyBiomarkerMiRNARheumatoid arthritis

Identifiers

PMID29744553
PMCPMC6154007
OpenAlexW2799926480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.