Evidence map›Paper›PMID 29744476›Full record

ArticleInvestigative and clinical urology2018

Prostate calcifications: A case series supporting the microbial biofilm theory.

Tommaso Cai, Francesco Tessarolo, Iole Caola, Federico Piccoli, Giandomenico Nollo, Patrizio Caciagli, Sandra Mazzoli, Alessandro Palmieri, Paolo Verze, Gianni Malossini and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Investigative and clinical urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. [Microbial etiology of bacterial chronic prostatitis: systematic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Efficacy of FlogofilmJournal of clinical medicine · 2023
    Article
  7. Article
  8. Article
  9. Review
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  11. The seminal microbiome in health and disease.Nature reviews. Urology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Tommaso CaiDepartment of Urology, Santa Chiara Regional Hospital, Trento, Italy.ORCID 0000-0002-7234-3526
Francesco TessaroloDepartment of Industrial Engineering, University of Trento, Trento, Italy.
Iole CaolaDepartment of Laboratory Medicine, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.
Federico PiccoliDepartment of Laboratory Medicine, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.
Giandomenico NolloDepartment of Industrial Engineering, University of Trento, Trento, Italy.
Patrizio CaciagliDepartment of Laboratory Medicine, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.
Sandra MazzoliSexually Transmitted Disease Centre, Santa Maria Annunziata Hospital, Florence, Italy.
Alessandro PalmieriDepartment of Urology, University of Naples, Naples, Italy.
Paolo VerzeDepartment of Urology, University of Naples, Naples, Italy.
Gianni MalossiniDepartment of Urology, Santa Chiara Regional Hospital, Trento, Italy.
Vincenzo MironeDepartment of Urology, University of Naples, Naples, Italy.
Truls E Bjerklund JohansenDepartment of Urology, Oslo University Hospital, Oslo, Norway.
Provincia Autonoma di Trento · ITUniversity of Naples Federico II · ITOspedale Santa Chiara · ITUniversity of Trento · ITOslo University Hospital · NOOspedale Santa Maria Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Prostate calcifications are a common finding during transrectal prostate ultrasound in both healthy subjects and patients, but their etiopathogenesis and clinical significance are not fully understood. We aimed to establish a new methodology for evaluating the role of microbial biofilms in the genesis of prostate calcifications. Materials and Methods: Ten consecutive patients who had undergone radical prostatectomy were enrolled in this study. All of the patients presented with prostate calcifications during transrectal ultrasound evaluation before surgery and underwent Meares-Stamey tests and clinical evaluation with the National Institutes of Health Chronic Prostatitis Symptom Index and the International Prostate Symptom Score. At the time of radical prostatectomy, the prostate specimen, after removal, was analyzed with ultrasonography under sterile conditions in the operating room. Core biopsy specimens were taken from the site of prostate calcification and subjected to ultrastructural and microbiological analysis. Results: The results of the Meares-Stamey test showed only 1 of 10 patients (10%) with positive cultures for Conclusions: Although the findings are supported by a low number of patients, this study highlights the validity of the proposed methodology for investigating the role of bacterial biofilms in the genesis of prostate calcification.

Indexed as

BiofilmsAgedBacteriological TechniquesBiopsyCalcinosisCitrobacter freundiiEnterococcus faecalisHumansMaleMicroscopy, Electrochemical, ScanningMiddle AgedProstateProstatectomyProstatic DiseasesUltrasonographyBiofilmsProstateProstate diseasesProstatitis

Identifiers

PMID29744476
PMCPMC5934281
OpenAlexW2794481750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.