ReviewBioactive materials2018
The development of collagen based composite scaffolds for bone regeneration.
Review in Bioactive materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
151 citing papers in PubMed, 427 citations in OpenAlex.
- High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.Bioactive materials · 2026Article
- Beyond Reinforcement: Collagen-Inorganic Composites as a Roadmap for Next-Generation Biomaterials.ACS materials Au · 2026Review
- Multimodal analysis of biomineralization within a collagen scaffolding in a rat calvarial defect model by using decalcified and undecalcified specimens.Journal of materials science. Materials in medicine · 2026Article
- Osteogenic Differentiation Properties of BLGFs/ODEX Hydrogel Doped With Collagen Derived FromInternational journal of biomaterials · 2026Article
- Modulating the crystallinity of biphasic calcium phosphate composites balances surface and ionic cues to enhance osteogenesis via integrin-mediated cytoskeletal signaling.Materials today. Bio · 2025Article
- Bioaugmented osteosynthesis: precise monitoring and intervention of the bone healing microenvironment.Bone research · 2025Article
- Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.ChemistryOpen · 2025Review
- 3D-Printed Multidimensional Bionic Mg-MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects.Advanced healthcare materials · 2025Article
- Dialdehyde Starch Cross-Linked Collagen with Heparin Conjugation: Characterization and Feasibility Study for Osteochondral Tissue Repair.Gels (Basel, Switzerland) · 2025Article
- Focal Adhesion of Collagen-Based Bone Grafting Materials Enhances Bone Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
- Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering.Bioactive materials · 2025Review
- Next-Generation Biomaterials for Load-Bearing Tissue Interfaces: Sensor-Integrated Scaffolds and Mechanoadaptive Constructs for Skeletal Regeneration.Journal of functional biomaterials · 2025Review
- Electrospun Poly(L-lactide-co-ε-caprolactone) Nanofibers with Hydroxyapatite Nanoparticles Mimic Cellular Interplay in Bone Regeneration.International journal of molecular sciences · 2025Article
- Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects.Biomedical engineering online · 2025Review
- Bioactivity of Marine-Derived Peptides and Proteins: A Review.Marine drugs · 2025Review
- The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches.Frontiers in bioengineering and biotechnology · 2025Review
- Categories, applications, and potential of stem cells in bone regeneration: an overview.Frontiers in medicine · 2025Review
- The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair.Gels (Basel, Switzerland) · 2024Review
- Tissue Sources Influence the Morphological and Morphometric Characteristics of Collagen Membranes for Guided Bone Regeneration.Polymers · 2024Article
- Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.Drug delivery · 2024Review
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone is consisted of bone matrix, cells and bioactive factors, and bone matrix is the combination of inorganic minerals and organic polymers. Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix. It plays an important role in the bone formation and remodeling process. Moreover, collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability. However, the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field. By incorporating different biomaterials, the properties such as porosity, structural stability, osteoinductivity, osteogenicity of collagen matrixes can be largely improved. This review summarizes and categorizes different kinds of biomaterials including bioceramic, carbon and polymer materials used as components to fabricate collagen based composite scaffolds for bone regeneration. Moreover, the possible directions of future research and development in this field are also proposed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.