Evidence map›Paper›PMID 29744447›Full record

ArticleBioactive materials2018

In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model.

Yuming Teng, Haiqiang Jin, Ding Nan, Mengnan Li, Chenghe Fan, Yuanyuan Liu, Pu Lv, Wei Cui, Yongan Sun, Hongjun Hao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yuming TengDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Haiqiang JinDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Ding NanDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Mengnan LiState Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chenghe FanDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Yuanyuan LiuDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Pu LvDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Wei CuiDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Yongan SunDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Hongjun HaoDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Xiaozhong QuCollege of Materials and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhenzhong YangState Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yining HuangDepartment of Neurology, Peking University First Hospital, Beijing 100034, China.
Peking University · CNChinese Academy of Sciences · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urokinase-type plasminogen activator (uPA) loaded hollow nanogels (nUK) were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly (ethylene oxide). The resultant formulation is sensitive to diagnostic ultrasound (US) of 2 MHz. Herein, we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery (MCA). Via intravenous (i.v.) administration, the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation, leading to enhanced thrombolysis efficiency of the nUK, evidenced from smaller infarct volume and better clinical scores when compared to the i.v. dose of free uPA no matter with or without US intervention. Meanwhile, the preservation ability of the nanogels not only prolonged the circulation duration of the protein, but also resulted in the better blood-brain barrier protection of the nUK formulation, showing no increased risk on the hemorrhagic transformation than the controls. This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke.

Indexed as

BBB, blood-brain barrierCCA, common carotid arteryEB, evens blueELIP, echogenic liposomesHb, hemoglobinHollow nanogelHT, hemorrhagic transformationIn vivo evaluationMCA, middle cerebral arteryMCAO, middle cerebral artery occlusionMRI, magnetic resonance imagingnUK, uPA-loaded nanogelsnUK+US, ultrasound and uPA-loaded nanogelsSD, Sprague-DawleyTCD, Transcranial DopplerThrombolysisTTC, 2,3,5-triphenyltetrazolium chlorideUK, urokinaseUK+US, ultrasound and free urokinaseUltrasound responsiveUrokinase deliveryUS, ultrasound

Identifiers

PMID29744447
PMCPMC5935765
OpenAlexW2748549515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.