ArticleBioactive materials2017
Fabrication of self-assembling nanofibers with optimal cell uptake and therapeutic delivery efficacy.
Article in Bioactive materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Hyaluronic acid-based osmolality-responsive immediate-release microneedles co-loading baicalein and astaxanthin for oral ulcer therapy.Materials today. Bio · 2026Article
- Magnetic Nanostructures for the Removal of Emerging Organic and Inorganic Pollutants: An Overview of Applications in Contaminated Water.Materials (Basel, Switzerland) · 2026Review
- Scalable electrospinning using a desktop, high throughput, self-contained system.Scientific reports · 2024Article
- A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β.Journal of nanobiotechnology · 2024Article
- In Situ Synthesis and Self-Assembly of Peptide-PEG Conjugates: A Facile Method for the Construction of Fibrous Hydrogels.Biomacromolecules · 2024Article
- Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity.Chembiochem : a European journal of chemical biology · 2021Article
- Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model.Bioactive materials · 2021Article
- New Biocomposite Electrospun Fiber/Alginate Hydrogel for Probiotic Bacteria Immobilization.Materials (Basel, Switzerland) · 2021Article
- Removal of heavy metals and radionuclides from water using nanomaterials: current scenario and future prospects.Environmental science and pollution research international · 2020Review
- Morphology and Mechanical Properties of 3Y-TZP Nanofiber Mats.Nanomaterials (Basel, Switzerland) · 2020Article
- Combined Tumor Environment Triggered Self-Assembling Peptide Nanofibers and Inducible Multivalent Ligand Display for Cancer Cell Targeting with Enhanced Sensitivity and Specificity.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Modular design and self-assembly of multidomain peptides towards cytocompatible supramolecular cell penetrating nanofibers.RSC advances · 2020Article
- A new prototype melt-electrospinning device for the production of biobased thermoplastic sub-microfibers and nanofibers.Biomaterials research · 2019Article
- Self-Assembled Antimicrobial Nanomaterials.International journal of environmental research and public health · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective strategies to fabricate finite organic nanoparticles and understanding their structure-dependent cell interaction is highly important for the development of long circulating nanocarriers in cancer therapy. In this contribution, we will capitalize on our recent development of finite supramolecular nanofibers based on the self-assembly of modularly designed cationic multidomain peptides (MDPs) and use them as a model system to investigate structure-dependent cell penetrating activity. MDPs self-assembled into nanofibers with high density of cationic charges at the fiber-solvent interface to interact with the cell membrane. However, despite the multivalent charge presentation, not all fibers led to high levels of membrane activity and cellular uptake. The flexibility of the cationic charge domains on self-assembled nanofibers plays a key role in effective membrane perturbation. Nanofibers were found to sacrifice their dimension, thermodynamic and kinetic stability for a more flexible charge domain in order to achieve effective membrane interaction. The increased membrane activity led to improved cell uptake of membrane-impermeable chemotherapeutics through membrane pore formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.