ReviewBioactive materials2017
Bone grafts and biomaterials substitutes for bone defect repair: A review.
Review in Bioactive materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 738 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
738 citing papers in PubMed, 1,909 citations in OpenAlex.
- Autogenous Demineralized Dentin Graft With High Molecular Weight Hyaluronic Acid in Ridge Preservation: Pilot Trial.Clinical implant dentistry and related research · 2025Trial
- Antral membrane balloon technique versus Densah bur in crestal sinus lift with simultaneous implant placement: a randomized clinical trial.BMC oral health · 2024Trial
- Advances in 3D bioprinting of immunoregulatory biomaterials for bone regeneration.Materials today. Bio · 2026Review
- An Injectable and Self-Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Combining gelatin methacryloyl hydrogels with mesenchymal stem cells: A versatile approach for bone tissue engineering.Histology and histopathology · 2026Review
- Neutrophils: The Overlooked Regenerative Role in Bone Repair.Stem cell reviews and reports · 2026Review
- Dimensional Accuracy and Clinical Fitness of Customized 3D-Printed Hydroxyapatite Bone Block Grafts in Alveolar Ridge Augmentation.European journal of dentistry · 2026Article
- A bioprinted periosteum organoid enables functional repair of critical-sized bone defects.Bioactive materials · 2026Article
- Article
- An integrated digital-to-surgical framework for patient-specific chest wall resection and reconstruction using 3D-printed titanium implants: proof-of-concept study.npj biomedical innovations · 2026Article
- Dynamic Biomaterial: A Platform for Biomedical Applications With Multiple Preparation Strategies.Macromolecular rapid communications · 2026Review
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dual-gene regulation of NGF overexpression and P75NTR knockdown enhances BMSC osteogenesis by suppressing pyroptosis.iScience · 2026Article
- 3D-Printed biodegradable and multifunctional cranial device for bone repair and healing assessment.Science advances · 2026Article
- A Functional TGF-β/Smad Assay for Targeted Profiling of Demineralized Bone Matrix-Derived Allograft Bioactivity.Journal of functional biomaterials · 2026Article
- Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026Review
- Development of biomimetic mouldable osseous scaffold engineered from bioactive decellularized extracellular matrix-polymer-gel composite: a potential bone substitute.Cell and tissue banking · 2026Article
- Multifunctional scaffold inspired by hepatocyte exosomes promotes bone regeneration by regulating osteogenic differentiation via PI3K/AKT pathway.Materials today. Bio · 2026Article
- Germanium-doped calcium phosphate ceramics in combination with mesenchymal stem cells derived from the neural crest, obtained from rabbit vibrissae: an experimental model of rabbit jaw regeneration.Archives of craniofacial surgery · 2026Article
- Silk Fibroin-Modified Titanium Implants for Bone Tissue Engineering: Structural Basis, Functionalization and Composite Strategies.Macromolecular bioscience · 2026Review
678 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.