ArticleBioactive materials2016
Research of a novel biodegradable surgical staple made of high purity magnesium.
Article in Bioactive materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- Current status and future prospects of biodegradable magnesium-based implants developed for orthopaedic applications.Journal of orthopaedic translation · 2026Review
- Tailoring the microstructure of biodegradable Zn-Cu-Li wires via thermo-mechanical processing towards high-performance surgical staples.Bioactive materials · 2026Article
- Functional design of anastomotic staples in gastrointestinal surgery: mechanistic insights and clinical translation.Biomedical engineering online · 2026Review
- Research Progress of Magnesium Alloys and Its Alloys in Medical Applications.International journal of general medicine · 2025Review
- Biodegradable high-nitrogen iron alloy anastomotic staples:Bioactive materials · 2024Article
- Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip.Journal of functional biomaterials · 2023Article
- A biodegradable magnesium surgical staple for colonic anastomosis:Bioactive materials · 2023Article
- The effect of enzymes on the in vitro degradation behavior of Mg alloy wires in simulated gastric fluid and intestinal fluid.Bioactive materials · 2022Article
- Biodegradable magnesium-based biomaterials: An overview of challenges and opportunities.MedComm · 2021Review
- The influence of Ca and Cu additions on the microstructure, mechanical and degradation properties of Zn-Ca-Cu alloys for absorbable wound closure device applications.Bioactive materials · 2021Article
- Regulatory science for hernia mesh: Current status and future perspectives.Bioactive materials · 2021Review
- The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wiresBioactive materials · 2021Article
- Novel zinc alloys for biodegradable surgical staples.World journal of clinical cases · 2020Article
- Translational status of biomedical Mg devices in China.Bioactive materials · 2019Article
- Biodegradable Surgical Staple Composed of Magnesium Alloy.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis. However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography (CT) and other imaging examination, and cause the risk of incorrect diagnosis. The bioabsorbable staple made from polymers that can degrade in human body environment, is an alternative. In the present study, biodegradable high purity magnesium staples were developed for gastric anastomosis. U-shape staples with two different interior angles, namely original 90° and modified 100°, were designed. Finite element analysis (FEA) showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape, while it concentrated on the feet for the modified staple after closure. The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion, whereas the modified one kept intact, demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples. The in vivo implantation showed good biocompatibility of the modified Mg staples, without inflammatory reaction 9 weeks post-operation. The Mg staples kept good closure to the Anastomosis, no leaking and bleeding were found, and the staples exhibited no fracture or severe corrosion cracks during the degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.