Evidence map›Paper›PMID 29744376›Full record

ArticleTechnology2017

Cell-sized lipid vesicles for cell-cell synaptic therapies.

D Vallejo, S H Lee, D Lee, C Zhang, C Rapier, S D Chessler, A P Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Solvent-Mediated Dewetting Principles for Cell-Sized Liposome Formation.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

D VallejoDepartment of Biomedical Engineering, University of California at Irvine, 3120 Natural Science Il, Irvine, California 92697, USA.
S H LeeDepartment of Biomedical Engineering, University of California at Irvine, 3120 Natural Science Il, Irvine, California 92697, USA.
D LeeSchool of Medicine, University of California at Irvine, 1001 Health Sciences Rd, Irvine, CA, 92617, USA.
C ZhangSchool of Medicine, University of California at Irvine, 1001 Health Sciences Rd, Irvine, CA, 92617, USA.
C RapierDepartment of Biomedical Engineering, University of California at Irvine, 3120 Natural Science Il, Irvine, California 92697, USA.
S D ChesslerSchool of Medicine, University of California at Irvine, 1001 Health Sciences Rd, Irvine, CA, 92617, USA.
A P LeeDepartment of Biomedical Engineering, University of California at Irvine, 3120 Natural Science Il, Irvine, California 92697, USA.
University of California, Irvine · US

Funding

Acoustic Trapping of Small Biological ParticlesR01EB012058 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2010 to 2013
$2.3M
Neuroligins and Neuroligin-Neurexin Interactions in Islet Beta Cell FunctionR01DK080971 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHESSLER, STEVEN D · 2009 to 2013
$1.7M
NIBIB NIH HHS R01 EB012058NIDDK NIH HHS R01 DK080971
6 · The paper itself

Abstract

Cell-sized lipid vesicles (CLVs) have shown great promise for therapeutic and artificial cell applications, but their fragility and short shelf life has hindered widespread adoption and commercial viability. We present a method to circumvent the storage limitations of CLVs such as giant unilamellar vesicles (GUVs) and single-compartment multisomes (SCMs) by storing them in a double emulsion precursor form. The double emulsions can be stored for at least 8 months and readily converted into either GUVs or SCMs at any time. In this study, we investigate the interfacial parameters responsible for this morphological change, and we also demonstrate the therapeutic potential of CLVs by utilizing them to present a transmembrane protein, neuroligin-2, to pancreatic β-cells, forming cell-cell synapses that stimulate insulin secretion and cellular growth.

Indexed as

Artificial CellsDewettingDouble EmulsionsDroplet MicrofluidicsGiant Unilamellar Vesicles

Identifiers

PMID29744376
PMCPMC5937847
OpenAlexW2786202447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.