ArticleInternational journal of applied & basic medical research
Inhibition of Spontaneous Contractility of Isolated Caprine Ureter by Flupirtine.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
contextKv7 potassium channels are expressed in several types of smooth muscles and could mediate physiological responses in the tissues expressed. Flupirtine is an analgesic that acts by opening Kv7 potassium channels. It has been shown to inhibit the contractility of several types of isolated smooth muscle.
aimsThis study investigated the ability of flupirtine to inhibit the spontaneous contractility of isolated distal caprine (goat) ureter. SETTINGS AND
designSpontaneous contractility of the isolated goat ureter was recorded using a physiograph. MATERIALS AND
methodsThe ability of 1, 3, 10, 30, and 90 μM concentrations of flupirtine maleate to inhibit the spontaneous contractility of isolated distal goat ureter was investigated. The ability of the nonspecific potassium channel blocker 4-aminopyridine (4-AP; 1 mM) and the specific Kv7 channel blocker XE-991 (100 μM) to reverse the inhibitory effect of flupirtine on ureteric contractility was also investigated. STATISTICAL ANALYSIS USED: Both parametric and nonparametric statistical tests were used.
resultsAt 10, 30, and 90 μM concentrations, flupirtine significantly inhibited the spontaneous contractility of the isolated goat ureter. The EC
conclusionsFlupirtine inhibits the spontaneous contractility of the isolated goat ureter by opening Kv7 channels.
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