ArticleTurkish journal of anaesthesiology and reanimation2018
High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice.
Article in Turkish journal of anaesthesiology and reanimation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Effects of Sublethal Organophosphate Toxicity and Anti-cholinergics on Electroencephalogram and Respiratory Mechanics in Mice.Frontiers in neuroscience · 2022Article
- Enhancing organophosphate hydrolase efficacy via protein engineering and immobilization strategies.Annals of the New York Academy of Sciences · 2020Review
- Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats.Molecules (Basel, Switzerland) · 2020Article
- The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents.Chemico-biological interactions · 2019Review
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveThe efficiency of pralidoxime in the treatment of human organophosphates poisoning is still unclear. In a rat model, we showed that pralidoxime induced a complete but concentration-dependent reversal of paraoxon-induced respiratory toxicity. The aim of this study was to assess the efficiency of pralidoxime in a species other than rats.
methodsA dose of diethylparaoxon corresponding to 50% of the median lethal dose was administered subcutaneously to male F1B6D2 mice. Ascending single pralidoxime doses of 10, 50-100 and 150 mg kg
resultsFrom 30 to 150 min post-injection, diethylparaoxon induced clinical symptoms and a decrease in respiratory frequency, which resulted from an increase in expiratory and inspiratory times associated with an increase in the tidal volume. In the 10-, 50- and 100-mg kg
conclusionIn the present study, a toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice was observed. By administering an equipotent dose of diethylparaoxon to rats, a 150 mg kg
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