ArticleTurkish journal of anaesthesiology and reanimation2018
Can Amantadine Ameliorate Neurocognitive Functions After Subarachnoid Haemorrhage? A Preliminary Study.
Article in Turkish journal of anaesthesiology and reanimation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.Neurocritical care · 2020Pooled it
- Prospective Evaluation of Icu Neurostimulant Use for Acute Brain Injury (Prevail): A Pragmatic Observational Cohort Study.Research square · 2026Article
- Neurostimulant Use for Rehabilitation and Recovery After Stroke: A Narrative Literature Review.Stroke · 2025Review
- Amantadine Continuation After Hospital Discharge for Acute Stroke Requiring Inpatient Rehabilitation: A Long-term Follow-up Study.Archives of rehabilitation research and clinical translation · 2025Article
- Informing future randomized controlled trials of amantadine hydrochloride in neurocritical care and post-neurocritical care stroke patients through a retrospective study.BMC neurology · 2024Article
- The impact of sleep problems on cerebral aneurysm risk is mediated by hypertension: a mediated Mendelian randomization study.Frontiers in genetics · 2024Article
- Management of Aneurysmal Subarachnoid Haemorrhage and its Complications: A Clinical Guide.Turkish journal of anaesthesiology and reanimation · 2023Article
- Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury.Journal of neurology, neurosurgery, and psychiatry · 2022Observational
- Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Does Neuroprotection Still Have a Role in Injured Brain Following Aneurysmal Subarachnoid Haemorrhage?Turkish journal of anaesthesiology and reanimation · 2018Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveAneurysmal subarachnoid haemorrhage (SAH) may have devastating effects on patients. Motor and neurocognitive impairments may arise depending on the location and grade of the SAH. Although the effects of amantadine on neurocognitive function after traumatic brain injury have been widely studied to the best of our knowledge, their effects on recovery from SAH in humans have not been studied. The present study aimed to evaluate how amantadine influences improvement in neurocognitive function in patients with aneurysmal SAH over a period of six months.
methodsThis preliminary study included 12 patients with aneurysmal SAH who were admitted to the neurointensive care unit of Cerrahpasa Faculty of Medicine. Patients in Group A (n=5) received the standard treatment for SAH and amantadine for 30 days after admission, and those in Group C (n=7) received only the standard treatment. Neurocognitive function was evaluated using the Coma Recovery Scale-Revised and Disability Rating Scale on the first and fifth days and at the third and sixth months after admission. The primary endpoint of the present study was to compare the effects of amantadine in combination with the standard treatment to those of the standard treatment alone on the neurocognitive function of patients with SAH for over 6 months.
resultsCompared to the standard treatment alone, amantadine administration with the standard treatment during the early period of SAH may improve recovery.
conclusionAmantadine along with the standard treatment can ameliorate neurocognitive function after SAH.
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