Evidence map›Paper›PMID 29743907›Full record

ArticlePostepy w kardiologii interwencyjnej = Advances in interventional cardiology2018

Circulating miRNA levels differ with respect to carotid plaque characteristics and symptom occurrence in patients with carotid artery stenosis and provide information on future cardiovascular events.

Rafal Badacz, Tadeusz Przewłocki, Jacek Gacoń, Ewa Stępień, Francisco J Enguita, Izabela Karch, Krzysztof Żmudka, Anna Kabłak-Ziembicka

Abstract read
In one paragraph

Article in Postepy w kardiologii interwencyjnej = Advances in interventional cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  20. miR-124 Is Downregulated in Serum of Acute Cerebral Infarct Patients and Shows Diagnostic and Prognostic Value.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rafal BadaczDepartment of Interventional Cardiology, School of Medicine, Jagiellonian University, John Paul II Hospital, Krakow, Poland.
Tadeusz PrzewłockiDepartment of Interventional Cardiology, School of Medicine, Jagiellonian University, John Paul II Hospital, Krakow, Poland.
Jacek GacońDepartment of Invasive Cardiology, E. Szczeklik's Hospital, Tarnow, Poland.
Ewa StępieńDepartment of Medical Physics, Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland.
Francisco J EnguitaInstitute of Molecular Medicine, Faculty of Medicine of Lisbon, Lisbon, Portugal.
Izabela KarchDepartment of Interventional Cardiology, School of Medicine, Jagiellonian University, John Paul II Hospital, Krakow, Poland.
Krzysztof ŻmudkaDepartment of Interventional Cardiology, School of Medicine, Jagiellonian University, John Paul II Hospital, Krakow, Poland.
Anna Kabłak-ZiembickaDepartment of Interventional Cardiology, School of Medicine, Jagiellonian University, John Paul II Hospital, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCirculating microRNAs (miRNAs) levels are potentially important biomarkers and therapeutic targets of cerebral ischemic event (CIE) in patients with internal carotid artery stenosis (ICAS).

aimThis prospective study investigated associations between circulating miRNAs and symptomatic and asymptomatic ICAS, carotid plaque morphology and future cardiovascular events. MATERIAL AND

methodsCirculating miRNAs (miR-1-3p, miR-16-5p, miR-34a-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were analyzed in 92 consecutive patients with significant ICAS referred for revascularization. Group I comprised 65 subjects (41 males, age 69.3 ±9.7 years) with a recent CIE. Group II comprised 27 patients (15 males, age 68.2 ±8.4 years) with asymptomatic ICAS. The ICAS degree and plaque morphology was assessed by ultrasonography. The incidences of cardiovascular death (CVD), myocardial infarction (MI) and recurrent CIE (CVD/MI/CIE) were recorded prospectively (mean: 38.7 ±3.8 months).

resultsGroups II and I differed significantly in levels of miR-124-3p (

conclusionsA significant difference in levels of selected miRNAs is observed in symptomatic vs. asymptomatic ICAS. Plaque morphology and structure is associated with change of miRNA levels. The expression of miR-1-3p may be a potential prognostic factor for future cardiovascular events.

Indexed as

biomarkerscarotid plaque morphologyinternal carotid artery stenosisischemic strokemiRNAsprognosis

Identifiers

PMID29743907
PMCPMC5939548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.