ArticleScientific reports2018
Genomic epidemiology of Shigella in the United Kingdom shows transmission of pathogen sublineages and determinants of antimicrobial resistance.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- A public resource of 15 genomically characterized representative strains ofMicrobial genomics · 2026Article
- Pathotype-specific antimicrobial resistance in diarrheagenicFrontiers in microbiology · 2026Review
- Evaluation of cross-functional antibody responses elicited by a four-component GMMA Shigella vaccine.NPJ vaccines · 2025Article
- Genomic and epidemiological characteristics ofPathogens and global health · 2025Article
- The emergence of sexually transmissibleMicrobial genomics · 2025Article
- Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England.Emerging infectious diseases · 2025Article
- Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions.Nature reviews. Microbiology · 2025Review
- The rise in domestic shigellosis and the genomic characteristics ofMicrobiology spectrum · 2025Article
- Trends in shigellosis notifications in England, January 2016 to March 2023.Epidemiology and infection · 2024Article
- Characterization of azithromycin-resistantMicrobiology spectrum · 2024Article
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- Multidrug-Resistant Shigellosis as a Sexually Transmitted Infection in Advanced HIV: A Case Report.Cureus · 2024Article
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- Genome-Wide Investigation Reveals Potential Therapeutic Targets inBioMed research international · 2024Article
- Analysis of Whole Genome Sequencing Data for Detection of Antimicrobial Resistance Determinants.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Shigella Serotypes Associated With Carriage in Humans Establish Persistent Infection in Zebrafish.The Journal of infectious diseases · 2023Article
- Whole genome sequencing of increased number of azithromycin-resistant Shigella flexneri 1b isolates in Ontario.Scientific reports · 2023Article
- Genomic reconstruction and directed interventions in a multidrug-resistant Shigellosis outbreak in Seattle, WA, USA: a genomic surveillance study.The Lancet. Infectious diseases · 2023Article
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12 authors.
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Abstract
Shigella are globally important diarrhoeal pathogens that are endemic in low-to-middle income nations and also occur in high income nations, typically in travellers or community-based risk-groups. Shigella phylogenetics reveals population structures that are more reliable than those built with traditional typing methods, and has identified sublineages associated with specific geographical regions or patient groups. Genomic analyses reveal temporal increases in Shigella antimicrobial resistance (AMR) gene content, which is frequently encoded on mobile genetic elements. Here, we whole genome sequenced representative subsamples of S. flexneri 2a and S. sonnei (n = 366) from the United Kingdom from 2008 to 2014, and analysed these alongside publicly available data to make qualitative insights on the genomic epidemiology of shigellosis and its AMR within the broader global context. Combined phylogenetic, epidemiological and genomic anlayses revealed the presence of domestically-circulating sublineages in patient risk-groups and the importation of travel-related sublineages from both Africa and Asia, including ciprofloxacin-resistant sublineages of both species from Asia. Genomic analyses revealed common AMR determinants among travel-related and domestically-acquired isolates, and the evolution of mutations associated with reduced quinolone susceptibility in domestically-circulating sublineages. Collectively, this study provides unprecedented insights on the contribution and mobility of endemic and travel-imported sublineages and AMR determinants responsible for disease in a high-income nation.
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