Evidence map›Paper›PMID 29743609›Full record

ArticleScientific reports2018

Salivary levels of total huntingtin are elevated in Huntington's disease patients.

Jody Corey-Bloom, Ameera S Haque, Sungmee Park, Ajay S Nathan, Robert W Baker, Elizabeth A Thomas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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  11. A Glimpse of Molecular Biomarkers in Huntington's Disease.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jody Corey-BloomDepartment of Neurosciences, University of California, San Diego, CA, USA.
Ameera S HaqueDepartment of Neurosciences, University of California, San Diego, CA, USA.
Sungmee ParkDepartment of Neurosciences, University of California, San Diego, CA, USA.
Ajay S NathanDepartment of Neurosciences, University of California, San Diego, CA, USA.
Robert W BakerDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Elizabeth A ThomasDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. bthomas@scripps.edu.
University of California, San Diego · USScripps Research Institute · US

Funding

Disease Modifying Potential of Glatiramer Acetate in Huntington's diseaseR21NS087986 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI THOMAS, ELIZABETH A · 2014 to 2015
$521k
Exploration of salivary huntingtin for biomarker discoveryR21NS111655 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMAS, ELIZABETH A · 2019 to 2020
$425k
NINDS NIH HHS R21 NS087986NINDS NIH HHS R21 NS111655
6 · The paper itself

Abstract

Patients with Huntington's disease (HD), an autosomal-dominant neurodegenerative disease, show substantial variability in age-of-onset, symptom severity and course of illness, warranting the need for biomarkers to anticipate and monitor these features. The HD gene encodes the disease protein huntingtin (Htt), a potentially useful biomarker for this disease. In the current study, we determined whether total Htt protein (normal plus mutant; "tHtt") could be reliably measured in human saliva, a body fluid that is much more accessible compared to cerebral spinal fluid or even blood, and whether salivary levels of tHtt were clinically meaningful. We collected 146 saliva samples from manifest HD patients, early-premanifest individuals, late-premanifest patients, gene-negative family members and normal controls. We found that tHtt protein could be reliably and stably detected in human saliva and that tHtt levels were significantly increased in saliva from HD individuals compared to normal controls. Salivary tHtt showed no gender effects, nor were levels correlated with total protein levels in saliva. Salivary tHtt was significantly positively correlated with age, but not age-of-onset or CAG-repeat length. Importantly, salivary tHtt was significantly correlated with several clinical measures, indicating relevance to disease symptom onset and/or severity. Measurements of salivary tHtt offer significant promise as a relevant, non-invasive disease biomarker for HD, and its use could be implemented into clinical applications.

Indexed as

AdultFemaleHumansHuntingtin ProteinHuntington DiseaseMaleMiddle AgedSalivaHTT protein, humanHuntingtin Protein

Identifiers

PMID29743609
PMCPMC5943337
OpenAlexW2802913059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.