ArticleScientific reports2018
Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: A novel potential marker for biodosimetry.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pilot clinical study of ascorbic acid treatment in cardiac catheterization.Journal of radiation research · 2019Trial
- Radiotherapy-Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments.MedComm · 2026Review
- IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents.International journal of radiation biology · 2025Article
- A comprehensive review of sensors of radiation-induced damage, radiation-induced proximal events, and cell death.Immunological reviews · 2025Review
- Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease.Gene therapy · 2024Article
- Analysis of whole-blood antioxidant capacity after chronic and localized irradiation using the i-STrap method.Journal of radiation research · 2022Article
- Radioprotective and Radiomitigative Effects of Melatonin in Tissues with Different Proliferative Activity.Antioxidants (Basel, Switzerland) · 2021Article
- Neurobehavioral effects of acute low-dose whole-body irradiation.Journal of radiation research · 2021Article
- Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants.Antioxidants (Basel, Switzerland) · 2021Article
- Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility.Journal of clinical biochemistry and nutrition · 2021Article
- Total body irradiation causes a chronic decrease in antioxidant levels.Scientific reports · 2021Article
- Identification of Potential Biomarkers of Radiation Exposure in Blood Cells by Capillary Electrophoresis Time-of-Flight Mass Spectrometry.International journal of molecular sciences · 2020Article
- Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment.Journal of proteome research · 2019Article
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Authors and funding
8 authors.
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Abstract
Many reports have demonstrated that radiation stimulates reactive oxygen species (ROS) production by mitochondria for a few hours to a few days after irradiation. However, these studies were performed using cell lines, and there is a lack of information about redox homeostasis in irradiated animals and humans. Blood redox homeostasis reflects the body condition well and can be used as a diagnostic marker. However, most redox homeostasis studies have focused on plasma or serum, and the anti-oxidant capacity of whole blood has scarcely been investigated. Here, we report changes in the anti-oxidant capacity of whole blood after X-ray irradiation using C57BL/6 J mice. Whole-blood anti-oxidant capacity was measured by electron spin resonance (ESR) spin trapping using a novel spin-trapping agent, 2-diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-oxide (DPhPMPO). We found that whole-blood anti-oxidant capacity decreased in a dose-dependent manner (correlation factor, r > 0.9; P < 0.05) from 2 to 24 days after irradiation with 0.5-3 Gy. We further found that the red blood cell (RBC) glutathione level decreased and lipid peroxidation level increased in a dose-dependent manner from 2 to 6 days after irradiation. These findings suggest that blood redox state may be a useful biomarker for estimating exposure doses during nuclear and/or radiation accidents.
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