ArticleScientific reports2018
Disruption of neonatal cardiomyocyte physiology following exposure to bisphenol-a.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Bisphenol A impairs contractile function and vascular development in human cardiac organoids: Insights from toxicity assessment and evidence-based risk evaluation.Journal of biomedical research · 2026Article
- Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update.Journal of cardiovascular development and disease · 2025Review
- Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring.Environmental toxicology and pharmacology · 2025Article
- Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Choice of experimental model determines translational impact: The link between bisphenol A and cardiotoxicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Article
- Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review.Journal of xenobiotics · 2022Review
- Characteristics of Bisphenol Cardiotoxicity: Impaired Excitability, Contractility, and Relaxation.Cardiovascular toxicology · 2022Review
- Cardiac toxicity from bisphenol A: Are electrophysiology and calcium handling perturbations dose-dependent?Toxicology and applied pharmacology · 2021Article
- Bisphenol A and its effects on the systemic organs of children.European journal of pediatrics · 2021Review
- Urinary levels of dimethoate, bisphenol A and benzo[a]pyrene in first-year students of Hohai University from different geographical regions.BMC public health · 2021Article
- Key Characteristics of Cardiovascular Toxicants.Environmental health perspectives · 2021Article
- Dense optical flow software to quantify cellular contractility.Cell reports methods · 2021Article
- Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart.Animals : an open access journal from MDPI · 2021Article
- Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes.Birth defects research · 2020Review
- Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.Scientific reports · 2020Article
- Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.American journal of physiology. Heart and circulatory physiology · 2020Article
- The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA).Neurotoxicity research · 2019Article
- Lights, camera, path splitter: a new approach for truly simultaneous dual optical mapping of the heart with a single camera.BMC biomedical engineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bisphenol chemicals are commonly used in the manufacturing of polycarbonate plastics, polyvinyl chloride plastics, resins, and thermal printing applications. Humans are inadvertently exposed to bisphenols through contact with consumer products and/or medical devices. Recent reports have shown a link between bisphenol-a (BPA) exposure and adverse cardiovascular outcomes; although these studies have been limited to adult subjects and models. Since cardiac physiology differs significantly between the developing and adult heart, we aimed to assess the impact of BPA exposure on cardiac function, using a neonatal cardiomyocyte model. Neonatal rat ventricular myocytes were monitored to assess cell viability, spontaneous beating rate, beat rate variability, and calcium-handling parameters in the presence of control or bisphenol-supplemented media. A range of doses were tested to mimic environmental exposure (10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.