ArticleScientific reports2018
Radioprotective effect of Date syrup on radiation- induced damage in Rats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Effects of Fractionated Low Dose Ionizing Radiation on Cellular Senescence in Mouse Lung Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- A Comprehensive Review on Date (Foods (Basel, Switzerland) · 2026Review
- Valorization of Date Palm (Molecules (Basel, Switzerland) · 2026Review
- Metabolomic and antioxidant characterization of seven Egyptian and Saudi date syrups via GC-MS and UHPLC/MS with sensory bioactive insights.Scientific reports · 2025Article
- The Effect of Resistance Training on Serum Levels of Lipid Profile and Liver Enzymes in Male Rat Undergoing Radiotherapy.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Protective Effects of Dexmedetomidine and Amifostine Against Radiotherapy-Induced Kidney Injury.Life (Basel, Switzerland) · 2025Article
- Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds.NeuroSci · 2024Review
- Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy.International journal of molecular sciences · 2024Review
- Radioprotective Effect of Piperine, as a Major Component of Black Pepper, Against Radiation-induced Colon Injury: Biochemical and Histological Studies.Current radiopharmaceuticals · 2024Article
- Radiation-induced Testicular Damage in Mice: Protective Effects of Apigenin Revealed by Histopathological Evaluation.Current radiopharmaceuticals · 2024Article
- The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats.Molecules (Basel, Switzerland) · 2023Article
- The Hepatoprotective Effect of Two Date Palm Fruit Cultivars' Extracts: Green Optimization of the Extraction Process.Foods (Basel, Switzerland) · 2023Article
- Bioactivity and Pharmacological Potential of Date Palm (Phoenix dactylifera L.) Against Pandemic COVID-19: a Comprehensive Review.Applied biochemistry and biotechnology · 2022Review
- Amelioration of radiation-induced liver damage byFood science and biotechnology · 2022Article
- Radiation-induced liver injury and hepatocyte senescence.Cell death discovery · 2021Review
- The effect of piracetam on behavioral reactions of adult rats and morphological changes in the brain after whole body fractionated gamma irradiation: an exploratory study.Radiation and environmental biophysics · 2021Article
- The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm.Brazilian journal of cardiovascular surgery · 2020Article
- The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats.Environmental science and pollution research international · 2019Article
- The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Clinical Significance of Kinetics of Low-Density Lipoprotein Cholesterol and Its Prognostic Value in Limited Stage Small Cell Lung Cancer Patients.Cancer control : journal of the Moffitt Cancer CenterObservational
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date syrup in rats subjected to whole body radiation at 6 Gy through biochemical, molecular and histopathological analysis. Significant elevations were recorded in the activities of serum ALT, AST, ALP and LDH and in the levels of all lipid profiles parameters, while the level of HDL-C was reduced. The concentration of liver MDA was elevated with depletion of hepatic glutathione (GSH) and catalase. DNA damage was evidenced by increased DNA strand breakage and DNA-protein crosslinks. Significant elevations were observed in the expression of liver TNF-α and serum activity of matrix metalloproteinase (MMP-9). Pretreatment of rats with Date syrup ameliorated the tissue damage induced by radiation as evidenced by the improvement of liver function, antioxidant status and reduction of DNA damage. Besides, liver TNF-α expression and serum MMP-9 activity were reduced. In conclusion, Date syrup could alleviate the toxic effects of ionizing radiation and thus is useful as a radioprotective in radiotherapy regimen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.