ArticleScientific reports2018
Chronic stress of high dietary carbohydrate level causes inflammation and influences glucose transport through SOCS3 in Japanese flounder Paralichthys olivaceus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 76 citations in OpenAlex.
- Dietary interaction of soybean oil and high starch impairs growth performance via metabolic-inflammatory dysregulation in Siberian sturgeon (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of different dietary starch sources on growth performance, hepatic antioxidant capacity, and muscle quality of adult grass carp (Food chemistry. Molecular sciences · 2026Article
- Effects of Varying Dietary Lipid and Starch Levels on Growth Performance, Biochemical Components, and Hepatic Glycolipid Metabolism in Hybrid Grouper (Animals : an open access journal from MDPI · 2026Article
- High Carbohydrate Feeding Exacerbates Oxidative Stress and Intestinal Dysfunction in Red Seabream (Pagrus major) after Skin Wounding.Marine biotechnology (New York, N.Y.) · 2026Article
- Transcriptomic responses and molecular mechanisms of glucagon-regulated glucose metabolism in Japanese flounder (Frontiers in physiology · 2026Article
- Transcriptome Profiling Unveils the Mechanisms of Inflammation, Apoptosis, and Fibrosis in the Liver of Juvenile Largemouth BassAnimals : an open access journal from MDPI · 2024Article
- High Starch Induces Hematological Variations, Metabolic Changes, Oxidative Stress, Inflammatory Responses, and Histopathological Lesions in Largemouth Bass (Metabolites · 2024Article
- Effects of Different Levels of Carbohydrates on Growth Performance, Hepatic and Intestinal Health, and Intestinal Microflora of Juvenile Pikeperch (Aquaculture nutrition · 2024Article
- Comparative study of immune responses and intestinal microbiota in the gut-liver axis between wild and farmed pike perch (Frontiers in immunology · 2024Article
- Selenium reduces hepatopancreas lipid accumulation of grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Article
- Study on Carbohydrate Metabolism in Adult Zebrafish (Aquaculture nutrition · 2023Article
- Dietary Corn Starch Levels Regulated Insulin-Mediated Glycemic Responses and Glucose Homeostasis in Swimming Crab (Aquaculture nutrition · 2022Article
- High-Carbohydrate Diet Alleviates the Oxidative Stress, Inflammation and Apoptosis ofAntioxidants (Basel, Switzerland) · 2021Article
- The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets.Scientific reports · 2021Article
- FoxO3 Modulates LPS-Activated Hepatic Inflammation in Turbot (Frontiers in immunology · 2021Article
- Dietary carbohydrates influence muscle texture of olive flounder Paralichthys olivaceus through impacting mitochondria function and metabolism of glycogen and protein.Scientific reports · 2020Article
- Revealing Alteration in the Hepatic Glucose Metabolism of Genetically Improved Carp, Jayanti RohuInternational journal of molecular sciences · 2020Article
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carnivorous fish is thought to be high-glucose intolerance. But the reasons were still unclear. The aim of the present study is to investigate the effects of high level of dietary carbohydrate on the survival, growth and immune responses of Paralichthys olivaceus, and the underlying molecular mechanism related to the immune and glucose metabolism. P. olivaceus were fed with 8%, 16% and 24% of dietary carbohydrate for 10 weeks, respectively. After that, a glucose tolerance test (GTT) was conducted. Results showed that excessive (24%) dietary carbohydrate significantly decreased the growth and glucose tolerance ability according to the GTT. It significantly increased hepatic NADPH oxidase activity and malondialdehyde content and serum contents of IL-6 and advanced glycation end products. The expressions of glucose transport-relevant genes in liver and the content of related hormones in serum were analyzed. In conclusion, it was confirmed that IL-6 increased the expression of suppressor of cytokine signaling 3 (SOCS3) and regulated the downstream targets of PI3K-AKT mediated signal transduction, and then downregulated the glucose transporter 2 activity in liver of P. olivaceus fed diet with excessive carbohydrate level. It was suggested that SOCS3 served as a bridge between immune response and glucose metabolism in P. olivaceus.
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