ArticleScientific reports2018
Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nanoplastic Disrupts Intestinal Homeostasis in Immature Rats by Altering the Metabolite Profile and Gene Expression.International journal of molecular sciences · 2025Article
- Role of a non-invasive multimodal brain monitoring approach in supplementing the clinical diagnosis of brain death: Observations from a case series.Indian journal of anaesthesia · 2025Article
- NMR-Based Metabolomics of Rat Hippocampus, Serum, and Urine in Two Models of Autism.Molecular neurobiology · 2022Article
- Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.Journal of biomedical optics · 2022Article
- Compressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media.Biomedical optics express · 2021Article
- Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy.Biomedical optics express · 2020Article
- Hippocampal Metabolite Profiles in Two Rat Models of Autism: NMR-Based Metabolomics Studies.Molecular neurobiology · 2020Article
- Influence of intra-abdominal pressure on the amplitude of fluctuations of cerebral hemoglobin concentration in the respiratory band.Biomedical optics express · 2019Article
- Self-calibrating time-resolved near infrared spectroscopy.Biomedical optics express · 2019Article
- Current Advancements in Transdermal Biosensing and Targeted Drug Delivery.Sensors (Basel, Switzerland) · 2019Review
- Frequency analysis of oscillations in cerebral hemodynamics measured by time domain near infrared spectroscopy.Biomedical optics express · 2019Article
- A Case of Persistence of Normal Tissue Oxygenation Monitored by Near-Infrared Spectroscopy (NIRS) Values Despite Prolonged Perioperative Cardiac Arrest.The American journal of case reports · 2019Article
- Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes.Biomedical optics express · 2018Article
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Authors and funding
10 authors.
Funding
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Abstract
We aimed to determine whether optical methods based on bolus tracking of an optical contrast agent are useful for the confirmation of cerebral circulation cessation in patients being evaluated for brain death. Different stages of cerebral perfusion disturbance were compared in three groups of subjects: controls, patients with posttraumatic cerebral edema, and patients with brain death. We used a time-resolved near-infrared spectroscopy setup and indocyanine green (ICG) as an intravascular flow tracer. Orthogonal partial least squares-discriminant analysis (OPLS-DA) was carried out to build statistical models allowing for group separation. Thirty of 37 subjects (81.1%) were classified correctly (8 of 9 control subjects, 88.9%; 13 of 15 patients with edema, 86.7%; and 9 of 13 patients with brain death, 69.2%; p < 0.0001). Depending on the combination of variables used in the OPLS-DA model, sensitivity, specificity, and accuracy were 66.7-92.9%, 81.8-92.9%, and 77.3-89.3%, respectively. The method was feasible and promising in the demanding intensive care unit environment. However, its accuracy did not reach the level required for brain death confirmation. The potential usefulness of the method may be improved by increasing the depth of light penetration, confirming its accuracy against other methods evaluating cerebral flow cessation, and developing absolute parameters for cerebral perfusion.
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