ArticleNature communications2018
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Biological applications at the AQUA beamline of the EuPRAXIA@SPARC_LAB free electron laser.European biophysics journal : EBJ · 2026Article
- Recent Advances in Amyloids Structural Studies and Thin Film Applications.Molecules (Basel, Switzerland) · 2025Review
- Advancing time-resolved structural biology: latest strategies in cryo-EM and X-ray crystallography.Nature methods · 2025Review
- Developments in Trapped Ion Mobility Mass Spectrometry to Probe the Early Stages of Peptide Aggregation.Journal of the American Society for Mass Spectrometry · 2023Article
- Ab initio reconstruction from one-dimensional crystal diffraction data.Acta crystallographica. Section A, Foundations and advances · 2022Article
- Wall-free droplet microfluidics for probing biological processes by high-brilliance X-ray scattering techniques.Frontiers in molecular biosciences · 2022Review
- Plug-and-play polymer microfluidic chips for hydrated, room temperature, fixed-target serial crystallography.Lab on a chip · 2021Article
- The XBI BioLab for life science experiments at the European XFEL.Journal of applied crystallography · 2021Article
- The three-dimensional structure of human β-endorphin amyloid fibrils.Nature structural & molecular biology · 2020Article
- A fixed-target platform for serial femtosecond crystallography in a hydrated environment.IUCrJ · 2020Article
- Hierarchical Ordered Assembly of Genetically Modifiable Viruses into Nanoridge-in-Microridge Structures.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- An outlook on using serial femtosecond crystallography in drug discovery.Expert opinion on drug discovery · 2019Review
- Coherent diffractive imaging of microtubules using an X-ray laser.Nature communications · 2019Article
- Imaging electron-density fluctuations by multidimensional X-ray photon-coincidence diffraction.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Oligomers Are Promising Targets for Drug Development in the Treatment of Proteinopathies.Frontiers in molecular neuroscience · 2019Article
- Biological single-particle imaging using XFELs - towards the next resolution revolution.IUCrJ · 2018Article
Corrections and comments
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Authors and funding
27 authors at 11 institutions in 8 countries.
Funding
Abstract
Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of femtosecond duration from an X-ray free-electron laser. Due to the very low background scattering from the graphene support and mutual alignment of filaments, diffraction from tobacco mosaic virus (TMV) filaments and amyloid protofibrils is obtained to 2.7 Å and 2.4 Å resolution in single diffraction patterns, respectively. Some TMV diffraction patterns exhibit asymmetry that indicates the presence of a limited number of axial rotations in the XFEL focus. Signal-to-noise levels from individual diffraction patterns are enhanced using computational alignment and merging, giving patterns that are superior to those obtainable from synchrotron radiation sources. We anticipate that our approach will be a starting point for further investigations into unsolved structures of filaments and other weakly scattering objects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.