Evidence map›Paper›PMID 29743371›Full record

ArticleJournal of virology2018

Roles of Fc Domain and Exudation in L2 Antibody-Mediated Protection against Human Papillomavirus.

Joshua W Wang, Wai Hong Wu, Tsui-Chin Huang, Margaret Wong, Kihyuck Kwak, Keiko Ozato, Chien-Fu Hung, Richard B S Roden

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  6. Review
  7. Multifaceted roles of Fcγ receptors in COVID-19 and vaccine responses.American journal of translational research · 2023
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Joshua W Wang *Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Wai Hong Wu *Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Tsui-Chin HuangDepartment of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Margaret WongDepartment of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Kihyuck KwakDepartment of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Keiko OzatoProgram in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Chien-Fu HungDepartment of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.
Richard B S RodenDepartment of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA roden@jhmi.edu.ORCID https://orcid.org/0000-0002-2506-0195
Johns Hopkins University · USNational Institutes of Health · US

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
Gene Regulation In The Immune SystemZIAHD001310 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI OZATO, KEIKO · 2009 to 2025
$15.0M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Papillomavirus-like Particles (VLP) as Broad Spectrum Human Papillomavirus (HPV) VaccinesR44AI136236 · NIAID · PATHOVAX, LLC · PI WANG, JOSHUA WEIYUAN · 2018 to 2020
$2.0M
NCI NIH HHS P50 CA098252NIAID NIH HHS R44 AI136236NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

To address how L2-specific antibodies prevent human papillomavirus (HPV) infection of the genital tract, we generated neutralizing monoclonal antibodies (MAbs) WW1, a rat IgG2a that binds L2 residues 17 to 36 (like mouse MAb RG1), and JWW3, a mouse IgG2b derivative of Mab24 specific for L2 residues 58 to 64. By Western blotting, WW1 recognized L2 of 29/34 HPV genotypes tested, compared to only 13/34 for RG1 and 25/34 for JWW3. WW1 IgG and F(ab')

Indexed as

Antibodies, NeutralizingAntibodies, ViralImmunoglobulin Fc FragmentsImmunoglobulin GAnimalsFemaleHistocompatibility Antigens Class IMiceMice, Inbred BALB CMice, KnockoutPapillomaviridaePapillomavirus InfectionsProtein DomainsRatsReceptors, FcAntibodies, NeutralizingAntibodies, ViralFc receptor, neonatalHistocompatibility Antigens Class IImmunoglobulin Fc FragmentsImmunoglobulin GReceptors, Fcantibody-mediated protectioncross-protectionFcFcRnhuman papillomavirushumoral immunityL2 proteinmonoclonal antibodyneutralizing antibodiesTRIM21

Identifiers

PMID29743371
PMCPMC6052307
OpenAlexW2801928211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.