Evidence map›Paper›PMID 29743310›Full record

ArticleJournal of clinical microbiology2018

Comparison of the QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-Tube Interferon Gamma Release Assays in Patients at Risk for Tuberculosis and in Health Care Workers.

Elitza S Theel, Heather Hilgart, Margaret Breen-Lyles, Kevin McCoy, Rhiannon Flury, Laura E Breeher, John Wilson, Irene G Sia, Jennifer A Whitaker, Jeremy Clain and 2 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comparing the Diagnostic Performance of QuantiFERON-TB Gold Plus to Other Tests of Latent Tuberculosis Infection: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Pooled it
  4. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India.Journal of clinical tuberculosis and other mycobacterial diseases · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review and Updates on the Diagnosis of Tuberculosis.Journal of clinical medicine · 2022
    Review
  19. Variability of interferon-γ release assays in people at high risk of tuberculosis infection or progression to tuberculosis disease living in the United States.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Elitza S TheelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA theel.elitza@mayo.edu.
Heather HilgartDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Margaret Breen-LylesOffice of Clinical Trials, Mayo Clinic, Rochester, Minnesota, USA.
Kevin McCoyMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Rhiannon FluryOlmsted County Public Health Services, Rochester, Minnesota, USA.
Laura E BreeherDivision of Preventive, Occupational and Aerospace Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
John WilsonMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Irene G SiaMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Jennifer A WhitakerMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Jeremy ClainMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Timothy R AksamitMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Patricio EscalanteMayo Clinic Center for Tuberculosis, Rochester, Minnesota, USA.
Mayo Clinic · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The QuantiFERON-TB Gold Plus (QFT-Plus; Qiagen, Germantown, MD) interferon gamma release assay (IGRA) received FDA clearance in 2017 and will replace the prior version of the assay, the QFT-Gold In-Tube (QFT-GIT). Here, we compared performances of the QFT-Plus assay and the QFT-GIT version in a diverse patient population, including patients undergoing evaluation for or follow-up of latent tuberculosis infection (LTBI;

Indexed as

AdolescentAdultAgedEmigrants and ImmigrantsFemaleHealth PersonnelHumansInterferon-gammaInterferon-gamma Release TestsLatent TuberculosisMaleMiddle AgedMinnesotaMycobacterium tuberculosisProspective StudiesTuberculosisIFNG protein, humanInterferon-gammaIGRALTBIQuantiFERON-TB Gold In-TubeQuantiFERON-TB Gold Plus

Identifiers

PMID29743310
PMCPMC6018330
OpenAlexW2800076529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.