Evidence map›Paper›PMID 29743302›Full record

ReviewJournal of clinical microbiology2018

The Continued Value of Disk Diffusion for Assessing Antimicrobial Susceptibility in Clinical Laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group.

Romney M Humphries, Susan Kircher, Andrea Ferrell, Kevin M Krause, Rianna Malherbe, Andre Hsiung, C A Burnham

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 86 citations in OpenAlex.

  1. Rapid delineation ofMicrobiology spectrum · 2026
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  12. Revisiting the Metallo-International journal of microbiology · 2025
    Review
  13. Article
  14. Anti-Heliyon · 2024
    Article
  15. Review
  16. Tick-tock, beat the clock: comparative analysis of disc diffusion testing with 6-, 10-, and 24-h growth for accelerated antimicrobial susceptibility testing and antimicrobial stewardship.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Romney M HumphriesAccelerate Diagnostics, Tucson, Arizona, USA rhumphries@axdx.com.
Susan KircherBecton, Dickinson and Company, Sparks, Maryland, USA.
Andrea FerrellBecton, Dickinson and Company, Sparks, Maryland, USA.
Kevin M KrauseAchaogen, Inc., South San Francisco, California, USA.
Rianna MalherbeHardy Diagnostics, Santa Maria, California, USA.
Andre HsiungHardy Diagnostics, Santa Maria, California, USA.
C A BurnhamDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-1137-840X
Becton Dickinson (United States) · USAccelerated Medical Diagnostics (United States) · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices. Antimicrobial disks for use with disk diffusion testing are among the first AST devices available to clinical laboratories. However, many laboratories are reluctant to implement disk diffusion testing for a variety of reasons, including dwindling proficiency with this method, interruptions of the laboratory workflow, uncertainty surrounding the quality and reliability of disk diffusion tests, and a perceived need to report MIC values to clinicians. This minireview provides a report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group on the current standards and clinical utility of disk diffusion testing.

Indexed as

Clinical Laboratory TechniquesDisk Diffusion Antimicrobial TestsHumansReference StandardsReproducibility of Resultsantimicrobial susceptibility testingCLSIdisk diffusionEUCASTFDA

Identifiers

PMID29743302
PMCPMC6062797
OpenAlexW2800267638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.