Evidence map›Paper›PMID 29743292›Full record

ArticleThe Journal of experimental medicine2018

Cholesterol negatively regulates IL-9-producing CD8

Xingzhe Ma, Enguang Bi, Chunjian Huang, Yong Lu, Gang Xue, Xing Guo, Aibo Wang, Maojie Yang, Jianfei Qian, Chen Dong and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 169 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Post-Translational Regulation of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Article
  8. The Role of Lipid Alteration in Multiple Sclerosis.International journal of molecular sciences · 2026
    Review
  9. Loss of LXRβ Drives CD4Biomedicines · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Targeting SQLE-mediated cholesterol metabolism to enhance CD8Journal for immunotherapy of cancer · 2025
    Article
  16. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xingzhe MaDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Enguang BiDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Chunjian HuangDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Yong LuDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-0532-160X
Gang XueDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Xing GuoDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Aibo WangInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.
Maojie YangDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Jianfei QianDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-4763-4409
Chen DongInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.ORCID 0000-0002-0084-9130
Qing YiDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH yiq@ccf.org.ORCID 0000-0003-1529-3398
Cleveland Clinic Lerner College of Medicine · USTsinghua University · CN

Funding

Targeting Plasmacytoid Dendritic Cells to Treat Human MyelomaR01CA163881 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YI, QING · 2012 to 2016
$2.0M
Role of MIF in myeloma bone homing and drug responseR01CA211073 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2017 to 2021
$1.8M
A novel T-cell subset able to kill relapsed cancersR01CA200539 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2016 to 2020
$1.8M
Targeting macrophages to sensitize myeloma to immune checkpoint blockadeR01CA214811 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YI, QING · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA163881NCI NIH HHS R01 CA200539NCI NIH HHS R01 CA211073NCI NIH HHS R01 CA214811
6 · The paper itself

Abstract

CD8

Indexed as

Cell DifferentiationAnimalsAntineoplastic AgentsCD8-Positive T-LymphocytesCell SurvivalCholesterolGene Expression RegulationHumansInterleukin-9Liver X ReceptorsMice, Inbred C57BLOxidation-ReductionOxysterolsSumoylationAntineoplastic AgentsCholesterolInterleukin-9Liver X ReceptorsOxysterols

Identifiers

PMID29743292
PMCPMC5987919
OpenAlexW2799988321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.