ArticleBMJ (Clinical research ed.)2018
Risk of stroke and transient ischaemic attack in patients with a diagnosis of resolved atrial fibrillation: retrospective cohort studies.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Bayesian Network Meta-analysis of Randomized Controlled Trials on the Efficacy of Antiarrhythmics in the Pharmacological Cardioversion of Paroxysmal Atrial Fibrillation.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Pooled it
- Appropriate intraprocedural initial heparin dosing in patients undergoing catheter ablation for atrial fibrillation receiving uninterrupted non-vitamin-K antagonist oral anticoagulant treatment.BMC cardiovascular disorders · 2021Trial
- Burden of cardiovascular disease in Japanese cancer patients and survivors: a single cancer-center study in Niigata City.International journal of clinical oncology · 2019Trial
- Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Trial
- Emergency Department Serum Electrolyte Patterns in Paroxysmal Atrial Fibrillation.Journal of clinical laboratory analysis · 2025Article
- Leveraging quality improvement initiatives to support development of decision support tools in healthcare.Health systems (Basingstoke, England) · 2025Article
- Thromboembolic events and vascular dementia in patients with atrial fibrillation and low apparent stroke risk.Nature medicine · 2024Article
- Article
- Generalisability of and lessons learned from a mixed-methods study conducted in three low- and middle-income countries to identify care pathways for atrial fibrillation.Global health action · 2023Article
- An economic evaluation of first-line cryoballoon ablation vs antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from a U.S. Medicare perspective.Heart rhythm O2 · 2023Article
- The risk of all-cause mortality associated with anxiety: a retrospective cohort study using 'The Health Improvement Network' database.BMC psychiatry · 2023Article
- Clinical efficacy and safety of Cox-maze IV procedure for atrial fibrillation in patients with aortic valve calcification.Frontiers in cardiovascular medicine · 2023Article
- Prevalence and outcomes of atrial fibrillation in older people living in care homes in Wales: a routine data linkage study 2003-2018.Age and ageing · 2022Article
- Article
- Observational
- Thromboembolic Risk in Patients With Pneumonia and New-Onset Atrial Fibrillation Not Receiving Anticoagulation Therapy.JAMA network open · 2022Article
- Association of RDW, NLR, and PLR with Atrial Fibrillation in Critical Care Patients: A Retrospective Study Based on Propensity Score Matching.Disease markers · 2022Article
- Atrial fibrillation occurring initially during acute medical illness: the heterogeneous nature of disease, outcomes and management strategies.European heart journal. Acute cardiovascular care · 2021Article
- Incidence and predictors of hospitalization in patients with atrial fibrillation: results from the Chinese atrial fibrillation registry study.BMC cardiovascular disorders · 2021Article
- Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine rates of stroke or transient ischaemic attack (TIA) and all cause mortality in patients with a diagnosis of "resolved" atrial fibrillation compared to patients with unresolved atrial fibrillation and without atrial fibrillation.
designTwo retrospective cohort studies.
settingGeneral practices contributing to The Health Improvement Network, 1 January 2000 to 15 May 2016.
participantsAdults aged 18 years or more with no previous stroke or TIA: 11 159 with resolved atrial fibrillation, 15 059 controls with atrial fibrillation, and 22 266 controls without atrial fibrillation.
main outcome measuresPrimary outcome was incidence of stroke or TIA. Secondary outcome was all cause mortality.
resultsAdjusted incidence rate ratios for stroke or TIA in patients with resolved atrial fibrillation were 0.76 (95% confidence interval 0.67 to 0.85, P<0.001) versus controls with atrial fibrillation and 1.63 (1.46 to 1.83, P<0.001) versus controls without atrial fibrillation. Adjusted incidence rate ratios for mortality in patients with resolved atrial fibrillation were 0.60 (0.56 to 0.65, P<0.001) versus controls with atrial fibrillation and 1.13 (1.06 to 1.21, P<0.001) versus controls without atrial fibrillation. When patients with resolved atrial fibrillation and documented recurrent atrial fibrillation were excluded the adjusted incidence rate ratio for stroke or TIA was 1.45 (1.26 to 1.67, P<0.001) versus controls without atrial fibrillation.
conclusionPatients with resolved atrial fibrillation remain at higher risk of stroke or TIA than patients without atrial fibrillation. The risk is increased even in those in whom recurrent atrial fibrillation is not documented. Guidelines should be updated to advocate continued use of anticoagulants in patients with resolved atrial fibrillation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.