Evidence map›Paper›PMID 29743244›Full record

ArticleThe Journal of biological chemistry2018

Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the

Shujie Shi, Stephanie M Mutchler, Brandon M Blobner, Ossama B Kashlan, Thomas R Kleyman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Acid-sensing ion channels in sensory signaling.American journal of physiology. Renal physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shujie ShiFrom the Renal-Electrolyte Division, Department of Medicine.
Stephanie M MutchlerFrom the Renal-Electrolyte Division, Department of Medicine.
Brandon M BlobnerFrom the Renal-Electrolyte Division, Department of Medicine.
Ossama B KashlanFrom the Renal-Electrolyte Division, Department of Medicine.
Thomas R KleymanFrom the Renal-Electrolyte Division, Department of Medicine, kleyman@pitt.edu.ORCID 0000-0002-2413-5415

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Biomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2M
Allosteric ENaC RegulationR01DK098204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2014 to 2018
$1.7M
SODIUM CHANNELS IN THE MAMMALIAN URINARY BLADDERR01DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R. · 1996 to 2005
$1.5M
Regulation of ENaC/degenerin channels by mechanical forcesK01DK103834 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2014 to 2018
$688k
NIDDK NIH HHS K01 DK103834NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK051391NIDDK NIH HHS R01 DK098204NIDDK NIH HHS R37 DK051391
6 · The paper itself

Abstract

The

Indexed as

Stress, MechanicalAmino AcidsAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCells, CulturedMembrane ProteinsMutagenesis, Site-DirectedMutationOocytesProtein ConformationSequence HomologyXenopus laevisAmino AcidsCaenorhabditis elegans ProteinsDeg-1 protein, C elegansMEC-10 protein, C elegansMec-4 protein, C elegansMembrane Proteinsacid sensing ion channel (ASIC)degenerinepithelial sodium channel (ENaC)gatingmechanotransductionporeshear stress

Identifiers

PMID29743244
PMCPMC6036219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.