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Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans.
Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Measles virus reprograms CD4Frontiers in cell and developmental biology · 2026Article
- Peste des petits ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue.Microbiology spectrum · 2025Article
- Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense.International journal of molecular sciences · 2025Review
- Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus.PLoS pathogens · 2023Article
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- Measles: Progress and Failure.The Ulster medical journal · 2021Article
- Article
- On invariant T cells and measles: A theory of "innate immune amnesia".PLoS pathogens · 2020Article
- Viropathic multinuclear syncytial giant cells in bronchial fluid from a patient with COVID-19.Journal of clinical pathology · 2020Article
- Seek and hide: the manipulating interplay of measles virus with the innate immune system.Current opinion in virology · 2020Review
- A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues.Science translational medicine · 2020Article
- Measles virus persistence and its consequences.Current opinion in virology · 2020Review
- Association of persistent wild-type measles virus RNA with long-term humoral immunity in rhesus macaques.JCI insight · 2020Article
- Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages.PLoS pathogens · 2020Article
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- Article
- Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium.Frontiers in immunology · 2019Article
- Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands.Nature communications · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Characterization of human measles cases is essential in order to better assess the data generated in model systems of morbillivirus infection. To this end, we collected formalin-fixed tissue samples from 23 natural measles cases from different areas in the world and different phases of disease ranging from prodromal and acute measles to a persistent infection in an immunocompromised subject. We show that the vast majority of measles virus (MV)-infected cells in epithelia were intraepithelial immune cells that were, in most cases, positive for the CD11c myeloid cell marker. Small numbers of measles virus-infected cytokeratin-positive epithelial cells were also detected in bronchial and appendix epithelia. Dissolution and disruption of uninfected and MV-infected alveolar and bronchial epithelia were prominent features of the measles cases, especially in the established and late phases of the disease. In some instances, this was associated with the formation of MV-infected multinucleated giant cells which expressed CD11c and/or macrophage cell marker 68, a pathological feature also prominently observed in closely associated mucosa-associated lymphoid tissue. Collectively, these data show that resident and inflammatory infiltrating immune cells alter the architecture of respiratory tract epithelia and highlight the necessity for additional research into the function(s) and expression of nectin-4 in human tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.