Evidence map›Paper›PMID 29743195›Full record

ArticleBioscience reports2018

Isovolumic loading of the failing heart by intraventricular placement of a spring expander attenuates cardiac atrophy after heterotopic heart transplantation.

Martin Pokorný, Iveta Mrázová, Jan Šochman, Vojtěch Melenovský, Jiří Malý, Jan Pirk, Lenka Červenková, Janusz Sadowski, Zdeněk Čermák, Karel Volenec and 4 more

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Martin PokornýDepartment of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Iveta MrázováDepartment of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Jan ŠochmanDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Vojtěch MelenovskýDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Jiří MalýDepartment of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Jan PirkDepartment of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Lenka ČervenkováCenter for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Janusz SadowskiDepartment of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Zdeněk ČermákELLA-CS, Ltd., Hradec Králové, Czech Republic.
Karel VolenecELLA-CS, Ltd., Hradec Králové, Czech Republic.
Šárka VackováCenter for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Hana MaxováDepartment of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Luděk ČervenkaDepartment of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic luce@medicon.cz.
Ivan NetukaDepartment of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Institute of Clinical and Experimental Medicine · CZCharles University · CZElla-Cs (Czechia) · CZPolish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac atrophy is the most common complication of prolonged application of the left ventricle (LV) assist device (LVAD) in patients with advanced heart failure (HF). Our aim was to evaluate the course of unloading-induced cardiac atrophy in rats with failing hearts, and to examine if increased isovolumic loading obtained by intraventricular implantation of an especially designed spring expander would attenuate this process. Heterotopic abdominal heart transplantation (HT

Indexed as

Heart TransplantationTissue Expansion DevicesAnimalsAortaAtrial Natriuretic FactorAtrophyBiomarkersDisease Models, AnimalEquipment DesignFibroblast Growth Factor 2FistulaGene ExpressionGlucose Transporter Type 1HeartHeart FailureHeart VentriclesAtp2a1 protein, ratAtrial Natriuretic FactorBiomarkersFibroblast Growth Factor 2Glucose Transporter Type 1Sarcoplasmic Reticulum Calcium-Transporting ATPasesSlc2a1 protein, ratCardiac atrophyheart failureheterotopic heart transplantationmechanical heart unloadingspring expander

Identifiers

PMID29743195
PMCPMC6019382
OpenAlexW2799459495

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.