SynthesisCirculation. Arrhythmia and electrophysiology2018
Clinical Implications of Ablation of Drivers for Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Synthesis in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of phase mapping and electrogram-based driver mapping for catheter ablation in atrial fibrillation.Pacing and clinical electrophysiology : PACE · 2019Pooled it
- Prospective Randomized Trial of Rotor Ablation vs Conventional Ablation for Persistent Atrial Fibrillation: REAFFIRM Trial.Journal of the American Heart Association · 2025Trial
- Catheter Ablation With Morphologic Repetitiveness Mapping for Persistent Atrial Fibrillation.JAMA network open · 2023Trial
- Focal Impulse and Rotor Modulation Ablation vs. Pulmonary Vein isolation for the treatment of paroxysmal Atrial Fibrillation: results from the FIRMAP AF study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Trial
- Online webinar training to analyse complex atrial fibrillation maps: A randomized trial.PloS one · 2019Trial
- Catheter configuration for mapping micro-anatomic reentries sustaining atrial fibrillation: A simulation study.PLoS computational biology · 2026Article
- Ablation of visually identified spatiotemporal dispersion plus pulmonary vein isolation in persistent atrial fibrillation.European heart journal open · 2026Article
- Segmental analysis of left atrial substrate severity predictors in patients undergoing persistent atrial fibrillation ablation.Frontiers in cardiovascular medicine · 2026Article
- Re-recognized the maintenance mechanism of persistent atrial fibrillation via electrogram analysis in termination regions.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Electrocardiographic Imaging as Preoperative Tool in Persistent and Long-Standing Persistent Atrial Fibrillation: A Prospective Observational Study.Interdisciplinary cardiovascular and thoracic surgery · 2025Observational
- Impact of Ablation Targeting Atrial Drivers and Fragmented Potentials on Long-Standing Persistent Atrial Fibrillation: A Retrospective Study.Journal of arrhythmia · 2025Article
- Comparing Phenotypes for Acute and Long-Term Response to Atrial Fibrillation Ablation Using Machine Learning.Circulation. Arrhythmia and electrophysiology · 2025Article
- Electrographic flow mapping of atrial fibrillation.Current opinion in cardiology · 2025Review
- 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Journal of arrhythmia · 2024Article
- Are drivers recurring or ephemeral? observations from serial mapping of persistent atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Navigating the Ebb and Flow of Atrial Fibrillation.JACC. Clinical electrophysiology · 2024Article
- Repeat ablation of atrial fibrillation using electrogram dispersion to identify additional areas of mechanistic significance.Heart rhythm O2 · 2024Article
- Mechanistic Insights From Trials of Atrial Fibrillation Ablation: Charting a Course for the Future.Circulation. Arrhythmia and electrophysiology · 2024Review
- Advanced Electroanatomic Mapping: Current and Emerging Approaches.Current treatment options in cardiovascular medicine · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe outcomes from pulmonary vein isolation (PVI) for atrial fibrillation (AF) are suboptimal, but the benefits of additional lesion sets remain unproven. Recent studies propose ablation of AF drivers improves outcomes over PVI, yet with conflicting reports in the literature. We undertook a systematic literature review and meta-analysis to determine outcomes from ablation of AF drivers in addition to PVI or as a stand-alone procedure.
methodsDatabase search was done using the terms atrial fibrillation and ablation or catheter ablation and driver or rotor or focal impulse or FIRM (Focal Impulse and Rotor Modulation). We pooled data using random effects model and assessed heterogeneity with I
resultsSeventeen studies met inclusion criteria, in a cohort size of 3294 patients. Adding AF driver ablation to PVI reported freedom from AF of 72.5% (confidence interval [CI], 62.1%-81.8%;
conclusionsIn controlled studies, the addition of AF driver ablation to PVI supports the possible benefit of a combined approach of AF driver ablation and PVI in improving single-procedure freedom from all arrhythmias. However, most studies are uncontrolled and are limited by substantial heterogeneity in outcomes. Large multicenter randomized trials are needed to precisely define the benefits of adding driver ablation to PVI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.