Evidence map›Paper›PMID 29743070›Full record

ArticleRespiratory research2018

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide.

Mark M Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J Halayko, Ian Adcock, Kian Fan Chung

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Disrupted HAntioxidants (Basel, Switzerland) · 2021
    Review
  5. Hydrogen Sulfide and the Immune System.Advances in experimental medicine and biology · 2021
    Article
  6. Article
  7. HIntensive care medicine experimental · 2020
    Review
  8. Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  9. Article
  10. Article
  11. HAmerican journal of physiology. Cell physiology · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mark M PerrySchool of Pharmacy & Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK. mark.perry@port.ac.uk.ORCID http://orcid.org/0000-0002-8145-8042
Bernadett TildyAirways Disease, National Heart and Lung Institute, Imperial College, London & Royal Brompton NIHR Biomedical Research Unit, London, SW3 6LY, UK.
Alberto PapiSezione di Medicina Interna e Cardiorespiratoria, Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo-Correlate (CEMICEF, formerly termed Centro di Ricerca su Asma e BPCO), Università di Ferrara, Ferrara, Italy.
Paolo CasolariSezione di Medicina Interna e Cardiorespiratoria, Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo-Correlate (CEMICEF, formerly termed Centro di Ricerca su Asma e BPCO), Università di Ferrara, Ferrara, Italy.
Gaetano CaramoriUnità Operativa Complessa di Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di Messina, Messina, Italy.
Karen Limbert RempelDepartments of Internal Medicine & Physiology, Respiratory Hospital, Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.
Andrew J HalaykoDepartments of Internal Medicine & Physiology, Respiratory Hospital, Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.
Ian AdcockAirways Disease, National Heart and Lung Institute, Imperial College, London & Royal Brompton NIHR Biomedical Research Unit, London, SW3 6LY, UK.
Kian Fan ChungAirways Disease, National Heart and Lung Institute, Imperial College, London & Royal Brompton NIHR Biomedical Research Unit, London, SW3 6LY, UK.
NIHR Royal Brompton Cardiovascular Biomedical Research Unit · GBUniversity of Messina · ITUniversity of Portsmouth · GB

Funding

Asthma UK 08/041Wellcome TrustWellcome Trust 085935
6 · The paper itself

Abstract

backbroundCOPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfide (H

methodsWe examined the effect of H

resultsExposure of ASM to H

conclusionsH

Indexed as

AgedAnti-Inflammatory AgentsCell ProliferationCells, CulturedFemaleHumansHydrogen SulfideInflammation MediatorsMaleMiddle AgedMyocytes, Smooth MusclePulmonary Disease, Chronic ObstructiveAnti-Inflammatory AgentsHydrogen SulfideInflammation MediatorsAirway smooth muscleCOPDCXCL8Hydrogen sulfideIL-6Proliferation

Identifiers

PMID29743070
PMCPMC5944010
OpenAlexW2801224719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.