ReviewJournal of Korean Neurosurgical Society2018
Intracranial Germ Cell Tumor in the Molecular Era.
Review in Journal of Korean Neurosurgical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Case Report: Occipital Mature Teratoma Mimicking Encephalocele in an Infant.Pediatric neurosurgery · 2026Article
- Infantile giant intracranial-extracranial communicating mixed germ cell tumor with ARID1B gene mutation: a case report.Frontiers in oncology · 2026Article
- Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study.Oncology research · 2026Article
- Comparison of treatment outcomes between combined chemotherapy-radiation therapy (chemo-RT) and radiation therapy alone (RT) for intracranial germ cell tumors in adolescent and young adult patients (AYA).Discover oncology · 2025Article
- Suprasellar teratoma to germinoma recurrence: implications for diagnosis and follow-up.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Imaging in malignant germ cell tumors involving the hypothalamo-neurohypophyseal axis: the evaluation of the posterior pituitary bright spot is essential.Neuroradiology · 2024Article
- Intratumoural haemorrhage in intracranial germ cell tumours: A review of literature with an illustrative case.World neurosurgery: X · 2024Review
- Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors.Acta neuropathologica communications · 2023Review
- Cancer Stem Cells in Tumours of the Central Nervous System in Children: A Comprehensive Review.Cancers · 2023Review
- A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome.Cancer medicine · 2023Review
- Histogenesis of intracranial germ cell tumors: primordial germ cell vs. embryonic stem cell.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Multiple ectopic germinomas presenting as focal dystonia of fingers: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Brain and Spinal Tumors Originating from the Germ Line Cells.Advances in experimental medicine and biology · 2023Article
- Update on MRI in pediatric intracranial germ cell tumors-The clinical and radiological features.Frontiers in pediatrics · 2023Review
- Diencephalic syndrome in a female child due to intracranial germinoma: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- Article
- Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes.CNS oncology · 2021Article
- Sacrococcygeal Teratoma : A Tumor at the Center of Embryogenesis.Journal of Korean Neurosurgical Society · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. However, for non-germinomatous GCT, current protocols provide only modest improvement and more innovative therapies are needed. Recently, next-generation sequencing studies have revealed the genomic landscape of iGCT. Novel mutations in the KIT-RAS-MAPK and AKT-MTOR pathways were identified. More importantly, methylation profiling revealed a new method to assess the pathogenesis of iGCT. Molecular research will unleash new knowledge on the origin of iGCT and solve the many mysteries that have lingered on this peculiar neoplasm for a long time.
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Registered trials
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