Evidence map›Paper›PMID 29742448›Full record

ArticleRespiratory physiology & neurobiology2018

Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury.

Katharine L Hamlington, Bradford J Smith, Celia M Dunn, Chantel M Charlebois, Gregory S Roy, Jason H T Bates

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Unshrinking the baby lung to calm the VILI vortex.Critical care (London, England) · 2022
    Review
  6. Article
  7. Review
  8. The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-induced Lung Injury.American journal of respiratory and critical care medicine · 2020
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katharine L HamlingtonDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA. Electronic address: katharine.h.smith@ucdenver.edu.
Bradford J SmithDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA. Electronic address: bradford.smith@ucdenver.edu.
Celia M DunnDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.
Chantel M CharleboisDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.
Gregory S RoyDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.
Jason H T BatesDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA. Electronic address: jason.h.bates@uvm.edu.
University of Vermont · US

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung InjuryR01HL142702 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Jason HT Bates, DONALD P. GAVER · 2018 to 2026
$4.6M
Personalized Mechanical Ventilation for the Injured LungR01HL124052 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BATES, JASON HT · 2014 to 2017
$2.4M
The Importance of Inhomogeneity in the Pathogenesis of Lung InjuryR00HL128944 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SMITH, BRADFORD J · 2017 to 2019
$747k
The Importance of Inhomogeneity in the Pathogenesis of Lung InjuryK99HL128944 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SMITH, BRADFORD J · 2015 to 2016
$224k
NHLBI NIH HHS K99 HL128944NHLBI NIH HHS R00 HL128944NHLBI NIH HHS R01 HL124052NHLBI NIH HHS R01 HL142702NHLBI NIH HHS T32 HL076122
6 · The paper itself

Abstract

Understanding how the mechanisms of ventilator-induced lung injury (VILI), namely atelectrauma and volutrauma, contribute to the failure of the blood-gas barrier and subsequent intrusion of edematous fluid into the airspace is essential for the design of mechanical ventilation strategies that minimize VILI. We ventilated mice with different combinations of tidal volume and positive end-expiratory pressure (PEEP) and linked degradation in lung function measurements to injury of the alveolar epithelium observed via scanning electron microscopy. Ventilating with both high inspiratory plateau pressure and zero PEEP was necessary to cause derangements in lung function as well as visually apparent physical damage to the alveolar epithelium of initially healthy mice. In particular, the epithelial injury was tightly associated with indicators of alveolar collapse. These results support the hypothesis that mechanical damage to the epithelium during VILI is at least partially attributed to atelectrauma-induced damage of alveolar type I epithelial cells.

Indexed as

Alveolar Epithelial CellsAnimalsDisease Models, AnimalFemaleLinear ModelsMice, Inbred BALB CMicroscopy, Electron, ScanningRespirationRespiratory Function TestsTidal VolumeVentilator-Induced Lung InjuryAcute respiratory distress syndromeAlveolar epithelial injuryLung function measurementMechanical ventilationScanning electron microscopy

Identifiers

PMID29742448
PMCPMC5986619
OpenAlexW2799581963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.