ArticleCell reports2018
ATF4 Regulates CD4
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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77citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Who cites it
77 citing papers in PubMed, 106 citations in OpenAlex.
- ATF4 orchestrates cancer hallmarks: Stress adaptation, metabolic reprogramming and immune suppression.iScience · 2026Review
- Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TScience advances · 2026Article
- Psoriasis-Obesity-Related Gene COX7C Promotes Keratinocyte Proliferation and Positively Regulates Inflammatory Responses in Psoriasis.Journal of cellular and molecular medicine · 2026Article
- Transcription Factor ATF4 Deletion Reprograms Glucose Metabolism in Clear Cell Renal Cell Carcinoma.Cancers · 2026Article
- Metabolic and transcriptional plasticity supports CD8Immunity · 2026Article
- ATF4: Orchestrating Cellular Stress Adaptation, Metabolism, and Immune Regulation in Health and Disease.International journal of molecular sciences · 2026Review
- Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation.Journal of virology · 2026Article
- Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026Review
- Glutathione-Mediated Redox Regulation of Immune Dysfunction in COVID-19 and Tuberculosis.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- The double-edged sword of regulatory T cells in MASLD: from inflammation control to fibrosis promotion.Animal cells and systems · 2026Review
- GCN2 in Cancer: Molecular Mechanisms to Therapeutic Potential.Current cancer drug targets · 2026Review
- Endoplasmic reticulum stress in Hashimoto's thyroiditis: a candidate amplification node linking thyroid-specific vulnerability and immune dysregulation.Frontiers in immunology · 2026Review
- The role of mitochondrial proteases in inflammation and immunity.Frontiers in immunology · 2026Review
- Amino Acid Metabolism in Chronic Liver Disease: from Pathogenic Driver to Therapeutic Target.International journal of biological sciences · 2026Review
- Targeting the unfolded protein response for cancer therapy: mitigating tumor adaptation and immune suppression.Biomarker research · 2025Review
- Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response.Nucleic acids research · 2025Article
- ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5.Acta biochimica et biophysica Sinica · 2025Article
- Harnessing nutrient scarcity for enhanced CAR-T-cell potency and safety in solid tumors.Cellular & molecular immunology · 2025Article
- Metabolic traits shape responses to LSD1-directed therapy in glioblastoma tumor-initiating cells.Science advances · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 8 institutions in 2 countries.
Xi YangDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; School of Medicine, Tsinghua University, HaiDian, Beijing 100084, China.
Rui XiaDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou 215007, China; The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
Cuihua YueDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Oncology, the Third Affiliated Hospital, Soochow University, Changzhou 213003, Jiangsu, China.
Wensi ZhaiDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Oncology, the Third Affiliated Hospital, Soochow University, Changzhou 213003, Jiangsu, China.
Wenwen DuDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Qianting YangDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Guangdong Key Laboratory for Emerging Infectious Disease, Shenzhen Key Laboratory of Infection and Immunity, Third People's Hospital, Guangdong Medical College, Shenzhen, Guangdong 518112, China.
Huiling CaoDepartment of Biology and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, Shenzhen 518055, China.
Xiaojuan ChenDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Danielle ObandoDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA.
Yibei ZhuDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Department of Immunology, Institute of Medical Biotechnology, Soochow University, Suzhou 215007, China.
Xinchun ChenGuangdong Key Laboratory for Emerging Infectious Disease, Shenzhen Key Laboratory of Infection and Immunity, Third People's Hospital, Guangdong Medical College, Shenzhen, Guangdong 518112, China.
Jane-Jane ChenInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jon PiganelliDivision of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Peter WipfDepartment of Chemistry and Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Yu JiangDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Guozhi XiaoDepartment of Biology and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, Shenzhen 518055, China.
Changping WuDepartment of Oncology, the Third Affiliated Hospital, Soochow University, Changzhou 213003, Jiangsu, China.
Jingting JiangDepartment of Oncology, the Third Affiliated Hospital, Soochow University, Changzhou 213003, Jiangsu, China.
Binfeng LuDepartment of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA; University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. Electronic address: binfeng@pitt.edu.
Soochow University · CNUniversity of Pittsburgh · USGuangdong Medical College · CNSouthern University of Science and Technology · CNChildren's Hospital of Pittsburgh · USFirst Affiliated Hospital of Soochow University · CNMassachusetts Institute of Technology · USUPMC Hillman Cancer Center · US
Funding
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6MRPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6MHRI-eIF2a Phosphorylation Signaling in Oxidative Stress and ErythropoiesisR01DK087984 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHEN, JANE-JANE · 2010 to 2017
$2.1MDissecting the role of the ATF4 stress response in T cell-mediated inflammationR21AI124676 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LU, BINFENG · 2016 to 2017
$425kNCATS NIH HHS UL1 TR000005NCI NIH HHS P50 CA097190NCI NIH HHS P50 CA159981NCRR NIH HHS UL1 RR024153NIAID NIH HHS R21 AI124676NIDDK NIH HHS R01 DK087984
Abstract
T cells are strongly regulated by oxidizing environments and amino acid restriction. How T cells reprogram metabolism to adapt to these extracellular stress situations is not well understood. Here, we show that oxidizing environments and amino acid starvation induce ATF4 in CD4
Indexed as
Activating Transcription Factor 4Amino AcidsAnimalsCD4-Positive T-LymphocytesCell ProliferationCell RespirationGene Expression RegulationGlutathioneGlycolysisLymphocyte ActivationMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMice, KnockoutOxidation-ReductionOxygen ConsumptionSulfhydryl CompoundsActivating Transcription Factor 4Amino AcidsGlutathioneMechanistic Target of Rapamycin Complex 1Sulfhydryl Compoundsamino acidATF4autoimmuneEAEglycolysismetabolismTCA cycleT cellTh1Th17
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