ArticleBiophysical journal2018
Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Importance of Bilayer Asymmetry in Biological Membranes: Insights from Model Membranes.Membranes · 2025Review
- Efficient calculation of orientation-dependent lipid dynamics from membrane simulations.bioRxiv : the preprint server for biology · 2024Article
- Unsaturated Lipids Facilitate Partitioning of Transmembrane Peptides into the Liquid Ordered Phase.Journal of chemical theory and computation · 2023Article
- Molecular simulations and NMR reveal how lipid fluctuations affect membrane mechanics.Biophysical journal · 2023Article
- The Effects of Cholesterol Oxidation on Erythrocyte Plasma Membranes: A Monolayer Study.Membranes · 2022Article
- The membrane transporter lactose permease increases lipid bilayer bending rigidity.Biophysical journal · 2021Article
- Single-molecule fluorescence vistas of how lipids regulate membrane proteins.Biochemical Society transactions · 2021Review
- Improved growth ofJournal of bacteriology · 2021Article
- The Effect of Phosphatidylserine on a pH-Responsive Peptide Is Defined by Its Noninserting End.Biophysical journal · 2019Article
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
A number of highly curved membranes in vivo, such as epithelial cell microvilli, have the relatively high sphingolipid content associated with "raft-like" composition. Given the much lower bending energy measured for bilayers with "nonraft" low sphingomyelin and low cholesterol content, observing high curvature for presumably more rigid compositions seems counterintuitive. To understand this behavior, we measured membrane rigidity by fluctuation analysis of giant unilamellar vesicles. We found that including a transmembrane helical GWALP peptide increases the membrane bending modulus of the liquid-disordered (Ld) phase. We observed this increase at both low-cholesterol fraction and higher, more physiological cholesterol fraction. We find that simplified, commonly used Ld and liquid-ordered (Lo) phases are not representative of those that coexist. When Ld and Lo phases coexist, GWALP peptide favors the Ld phase with a partition coefficient of 3-10 depending on mixture composition. In model membranes at high cholesterol fractions, Ld phases with GWALP have greater bending moduli than the Lo phase that would coexist.
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Registered trials
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