Evidence map›Paper›PMID 29742407›Full record

ArticleBiophysical journal2018

Mechanism of Long-Chain Free Fatty Acid Protonation at the Membrane-Water Interface.

Alina A Pashkovskaya, Mario Vazdar, Lars Zimmermann, Olga Jovanovic, Peter Pohl, Elena E Pohl

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
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  5. Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  8. pEnvironmental science & technology · 2025
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  14. Article
  15. Article
  16. Article
  17. A protein-lipid complex that detoxifies free fatty acids.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Alina A PashkovskayaInstitute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
Mario VazdarDivision of Organic Chemistry and Biochemistry, Rudjer Bošković Institute, Zagreb, Croatia.
Lars ZimmermannInstitute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
Olga JovanovicInstitute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
Peter PohlInstitute of Biophysics, Johannes Kepler University, Linz, Austria. Electronic address: peter.pohl@jku.at.
Elena E PohlInstitute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria. Electronic address: elena.pohl@vetmeduni.ac.at.
University of Veterinary Medicine Vienna · ATJohannes Kepler University of Linz · ATRudjer Boskovic Institute · HR

Funding

Austrian Science Fund FWF P 25357Austrian Science Fund FWF P 25981
6 · The paper itself

Abstract

Long-chain free fatty acids (FFAs) play an important role in several physiological and pathological processes such as lipid fusion, adjustments of membrane permeability and fluidity, and the regulation of enzyme and protein activities. FFA-facilitated membrane proton transport (flip-flop) and FFA-dependent proton transport by membrane proteins (e.g., mitochondrial uncoupling proteins) are governed by the difference between FFA's intrinsic pK

Indexed as

ProtonsCell MembraneFatty Acids, NonesterifiedHydrogen-Ion ConcentrationMolecular ConformationMolecular Dynamics SimulationSurface PropertiesUnilamellar LiposomesWaterFatty Acids, NonesterifiedProtonsUnilamellar LiposomesWater

Identifiers

PMID29742407
PMCPMC5961518
OpenAlexW2801771484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.