ArticleStem cell reports2018
Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.
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Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
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- Promoting and accelerating muscle regeneration through cell therapy in a mouse model.Journal of Taibah University Medical Sciences · 2024Article
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- A Self-Renewing Biomimetic Skeletal Muscle Construct Engineered using Induced Myogenic Progenitor Cells.Advanced functional materials · 2024Article
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- MicroRNA-142a-3p regulates neurogenic skeletal muscle atrophy by targeting Mef2a.Molecular therapy. Nucleic acids · 2023Article
- Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells.NPJ Regenerative medicine · 2023Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 4 countries.
Ori Bar-NurDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, 8603 Schwerzenbach, Switzerland.
Mattia F M GerliCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Bruno Di StefanoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Albert E AlmadaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA.
Amy GalvinCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Amy CoffeyDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Aaron J HuebnerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Peter FeigeSprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada.
Cassandra VerheulDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Priscilla CheungDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Duygu Payzin-DogruDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Sylvain PaisantStem Cells and Development Unit, Department of Developmental & Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Institut Pasteur, Paris, France.
Anthony AnselmoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Harald C OttCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Shahragim TajbakhshStem Cells and Development Unit, Department of Developmental & Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Institut Pasteur, Paris, France.
Michael A RudnickiSprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada.
Amy J WagersDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA.
Konrad HochedlingerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: khochedlinger@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard Stem Cell Institute · USCentre National de la Recherche Scientifique · FRHarvard University · USETH Zurich · CHUniversity College London · GB
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6MRoles of sumoylation and alternative polyadenylation in cellular reprogrammingP01GM099134 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PLATH, KATHRIN · 2011 to 2021
$20.3MGENETIC REGULATION OF SKELETAL MUSCLE REPAIRR01AR044031 · NIAMS · OTTAWA HOSPITAL RESEARCH INSTITUTE · PI RUDNICKI, MICHAEL A · 1996 to 2025
$5.6MTranscription Factor Induced ReprogrammingR01HD058013 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHEDLINGER, KONRAD · 2010 to 2019
$4.4MRegulation and Function of Growth Differentiation Factor 11 During Development and AgingR01AG048917 · NIA · HARVARD UNIVERSITY · PI WAGERS, AMY JO · 2016 to 2020
$2.8MEpigenomic drivers of human muscle progenitor cells in development and diseaseR01ES024935 · NIEHS · HARVARD UNIVERSITY · PI WAGERS, AMY JO · 2014 to 2015
$656kCIHR FDN-148387NIAMS NIH HHS R01 AR044031NIA NIH HHS R01 AG048917NICHD NIH HHS R01 HD058013NIDDK NIH HHS P30 DK040561NIEHS NIH HHS R01 ES024935NIGMS NIH HHS P01 GM099134
Abstract
Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors termed myoblasts, which play pivotal roles during muscle regeneration. However, current technology does not allow permanent capture of these cell populations in vitro. Here, we show that ectopic expression of the myogenic transcription factor MyoD, combined with exposure to small molecules, reprograms mouse fibroblasts into expandable induced myogenic progenitor cells (iMPCs). iMPCs express key skeletal muscle stem and progenitor cell markers including Pax7 and Myf5 and give rise to dystrophin-expressing myofibers upon transplantation in vivo. Notably, a subset of transplanted iMPCs maintain Pax7 expression and sustain serial regenerative responses. Similar to satellite cells, iMPCs originate from Pax7
Indexed as
Cellular ReprogrammingAnimalsBiomarkersCell DifferentiationCell Self RenewalFibroblastsMiceMuscle DevelopmentMuscle Fibers, SkeletalMuscle, SkeletalMuscular Dystrophy, AnimalMyoD ProteinPAX7 Transcription FactorRegenerationSatellite Cells, Skeletal MuscleSmall Molecule LibrariesBiomarkersMyoD ProteinPAX7 Transcription FactorSmall Molecule Librariesdirect lineage reprogramminginduced muscle progenitor cellsmuscular dystrophyMyoDPax7satellite cellsskeletal musclesmall moleculestransplantation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.