ArticleAnnals of the American Thoracic Society2018
Association between Obstructive Sleep Apnea and Cardiovascular Risk Factors: Variation by Age, Sex, and Race. The Multi-Ethnic Study of Atherosclerosis.
Article in Annals of the American Thoracic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Racial and Ethnic Disparities in the Diagnosis and Treatment of Obstructive Sleep Apnea: A Systematic Review.International journal of environmental research and public health · 2026Pooled it
- Association between elevated cystatin C levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Sex-Specific Differential Responses of Circulating Biomarkers in Obstructive Sleep Apnea Treatment. AAnnals of the American Thoracic Society · 2020Trial
- Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary study.Nutrition & diabetes · 2019Trial
- The effect of gender on clinical characteristics and diagnostic process of obstructive sleep apnea syndrome.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Varying Hypopnea Definitions and Treatment Eligibility in Obstructive Sleep Apnea.Sleep & breathing = Schlaf & Atmung · 2026Article
- The association between obstructive sleep apnea risk and cardiovascular disease risk in midlife Thai women in the U.S.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Exploring the cardiometabolic profile of Emirati adults at risk for obstructive sleep apnea: findings from the UAE healthy future study.Frontiers in sleep · 2026Article
- Comparison of oxygen desaturation area-based methods in predicting cardiovascular disease-related mortality outcomes.Frontiers in network physiology · 2026Article
- Insomnia, Sleep Apnea, and Incidence of Hypertension and Cardiovascular Disease Among Men and Women US Veterans.Journal of the American Heart Association · 2025Article
- Age matters: the differential impact of OSA on metabolic health by age group.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Effect of age on the association of obstructive sleep apnea with metabolic syndrome among obese and nonobese adults.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Demographic and modifiable risk factors impacting obstructive sleep apnea comorbidities: a New Orleans case-control study.Sleep & breathing = Schlaf & Atmung · 2025Article
- C-reactive protein improves the ability to detect hypertension and insulin resistance in mild-to-moderate obstructive sleep apnea: Age effect.Journal of sleep research · 2025Article
- The relationship between obesity and obstructive sleep apnea in four community-based cohorts: an individual participant data meta-analysis of 12,860 adults.EClinicalMedicine · 2025Article
- Quantitative study on whole brain volume in patients with obstructive sleep apnea based on synthetic magnetic resonance imaging.BMC medical imaging · 2025Article
- Article
- Continuous positive airway pressure in acute ischemic stroke patients with obstructive sleep apnea: analysis of the National Inpatient Sample database.Frontiers in neurology · 2025Article
- Evaluating cystatin-C and monocyte-to-high-density lipoprotein cholesterol ratio as indicators of obstructive sleep apnea severity in male patients.Frontiers in cardiovascular medicine · 2025Article
- Racial and ethnic differences in the receipt of continuous positive airway pressure treatment for obstructive sleep apnea.Sleep medicine · 2024Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
rationaleThe association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) is complex, bidirectional, and may vary across groups. Understanding which cardiovascular risk factors vary in their relationship to OSA across population groups may improve knowledge of OSA-related CVD susceptibility.
objectivesTo better understand the heterogeneity of associations, we assessed whether associations of OSA with cardiovascular risk factors vary by age, sex, and race/ethnicity.
methodsWe performed cross-sectional analyses of 1,344 Multi-Ethnic Study of Atherosclerosis participants who underwent overnight full polysomnography, assays of fasting blood, and assessments of cardiovascular risk factors. Risk factors considered were blood pressure, glucose/lipid concentrations, white blood cell (WBC) total and subset counts, and cystatin C. The outcome was the apnea-hypopnea index (AHI). Linear regression analyses with tests for interactions were conducted.
resultsThe sample had a mean age of 68 ± 9 years. Forty-seven percent of the sample was male, and 32% had moderate or severe OSA (AHI, ≥15). Multivariable adjusted analysis showed significant associations between higher AHI with lower high-density lipoprotein cholesterol and higher diastolic blood pressure and neutrophil counts. Significant interactions with demographic factors were observed. Stronger associations were shown between AHI and higher total WBC count (P
conclusionsIn a multiethnic cohort, we found increased levels of cardiovascular risk factors in association with OSA, including elevated neutrophil counts, a marker of inflammation. Furthermore, several associations were stronger in men, younger individuals, and African American individuals, highlighting pathways for CVD risk that may explain heterogeneity in the associations between CVD and OSA across population groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.