ArticleCancer2018
Development of a novel salivary gland cancer lymph node staging system.
Article in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Survival and prognostic factors of parotid malignancies in Northern Italy: a multicentric study.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Article
- Neck Management in Malignant Parotid Tumors: A Retrospective Analysis of Elective Neck Dissection Indications and Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Number and ratio of positive lymph nodes predict survival in pediatric salivary gland cancer.Scientific reports · 2025Article
- Intra-parotid lymph node metastasis in primary parotid gland cancer: a narrative review of its significance, anatomic distribution, and therapeutic implications.Gland surgery · 2025Review
- Prognostic factors for development of distant metastases in surgically treated high-grade salivary gland carcinomas: results of retrospective single center study with 213 patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- The 8th AJCC classification is inferior to a new neck stage based on intraparotid lymph node in parotid gland cancer.BMC oral health · 2024Article
- Number of positive lymph nodes affects oncologic outcomes in cN0 mucoepidermoid carcinoma of the major salivary gland.Scientific reports · 2024Article
- Editorial: Diagnosis, epidemiology and treatment of salivary gland carcinomas.Frontiers in oncology · 2024Article
- Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma.Scientific reports · 2023Article
- Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?Turkish archives of otorhinolaryngology · 2023Article
- Metastatic lymph node burden impacts overall survival in submandibular gland cancer.Frontiers in oncology · 2023Article
- Number of positive lymph nodes affects outcomes in parotid adenoid cystic carcinoma.Frontiers in oncology · 2023Article
- Current management and future challenges in salivary glands cancer.Frontiers in oncology · 2023Review
- Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer.PloS one · 2023Article
- Nodal Metastasis Count and Oncologic Outcomes in Head and Neck Cancer: A Secondary Analysis of NRG/RTOG 9501, NRG/RTOG 0234, and EORTC 22931.International journal of radiation oncology, biology, physics · 2022Article
- Quantitative Nodal Burden and Mortality Across Solid Cancers.Journal of the National Cancer Institute · 2022Article
- Salivary gland function, development, and regeneration.Physiological reviews · 2022Review
- [Application of free peroneal artery chimeric perforator flap in repairing the defect after advanced local lesions resection in parotid gland carcinoma].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Article
- Diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in sublingual and submandibular salivary gland tumors.Molecular and clinical oncology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCurrent lymph node (LN) staging for salivary gland cancer (SGC) is extrapolated from mucosal head and neck squamous cell carcinoma. However, given its unique biology and clinical behavior, it is possible that a SGC-specific LN staging system would be more accurate.
methodsPatients from the National Cancer Data Base with nonmetastatic SGC of the head and neck who were diagnosed from 2004 through 2013 and underwent surgical resection and neck dissection removing at least 10 LNs were included. Multivariable models were constructed to assess the association between survival and LN factors, including number of metastatic LNs, extranodal extension, LN size, and lower LN involvement.
resultsOverall, 4520 patients met the inclusion criteria. An increasing number of metastatic LNs was found to be strongly associated with worse survival without plateau. The risk of death increased more rapidly up to 4 LNs (hazard ratio, 1.34; 95% confidence interval, 1.27-1.41 [P < .001]), and was more gradual for additional LNs >4 (hazard ratio, 1.02; 95% confidence interval, 1.01-1.03 [P < .001]). LN size, extranodal extension, and lower LN involvement appeared to have no impact on survival when accounting for the number of metastatic LNs. Recursive partitioning analysis was used to create a novel SGC LN staging system in which N0 indicates 0 positive LNs, N1 indicates 1 to 2 positive LNs, N2 indicates 3 to 21 positive LNs, and N3 indicates ≥ 22 positive LNs. This system exhibited greater concordance than the current American Joint Committee on Cancer (eighth edition) system.
conclusionsQuantitative LN burden is an important determinant of survival in patients with SGC. Use of this variable may improve SGC staging. Cancer 2018. © 2018 American Cancer Society.
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