ArticleJournal of applied oral science : revista FOB2018
Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study.
Article in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical evidence of photobiomodulation therapy (PBMT) on implant stability and success: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Photobiomodulation With 976 nm Diode Laser Enhances Osteoblastic Differentiation of Saos-2 Cells Cultured on Collagen Membranes.Clinical and experimental dental research · 2026Article
- Heterologous Fibrin Biopolymer as a Key Scaffold for Bone Regeneration: Synergistic Effects with Photobiomodulation and Membrane Therapy.Gels (Basel, Switzerland) · 2026Article
- Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation.Materials (Basel, Switzerland) · 2025Article
- Biofunctional response of a synthetic ceramic of 99.9% tricalcium phosphate associated with a heterologous fibrin biopolymer and infrared photobiomodulation.Frontiers in bioengineering and biotechnology · 2025Article
- Photobiomodulation and Inorganic Bovine Bone in Guided Bone Regeneration: Histomorphometric Analysis in Rats.Journal of functional biomaterials · 2023Article
- Tissue Bioengineering with Fibrin Scaffolds and Deproteinized Bone Matrix Associated or Not with the Transoperative Laser Photobiomodulation Protocol.Molecules (Basel, Switzerland) · 2023Article
- LED photobiomodulation therapy combined with biomaterial as a scaffold promotes better bone quality in the dental alveolus in an experimental extraction model.Lasers in medical science · 2022Article
- Texturized P(VDF-TrFE)/BT membrane enhances bone neoformation in calvaria defects regardless of the association with photobiomodulation therapy in ovariectomized rats.Clinical oral investigations · 2022Article
- Effect of Photobiomodulation Therapy Associated With Biphasic Phosphate Calcium on Bone Repair: A Histomorphometric Study in Rats.Journal of lasers in medical sciences · 2022Article
- Bone repair assessment of critical size defects in rats treated with mineralized bovine bone (Bio-Oss®) and photobiomodulation therapy: a histomorphometric and immunohistochemical study.Lasers in medical science · 2021Article
- Photobiomodulation Therapy on the Guided Bone Regeneration Process in Defects Filled by Biphasic Calcium Phosphate Associated with Fibrin Biopolymer.Molecules (Basel, Switzerland) · 2021Article
- Effect of low-level laser therapy on the membrane induced by the Masquelet technique at an orthotopic site in rabbits.Acta cirurgica brasileira · 2021Article
- Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects.Journal of bone and mineral metabolism · 2020Article
- Photobiomodulation guided healing in a sub-critical bone defect in calvarias of rats.Laser therapy · 2019Article
- The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.Journal of applied oral science : revista FOB · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05). Results All groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%). Conclusion The PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques.
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