ArticleMolecular biology of the cell2018
Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Dynamic microtubules as sensors in animal cells.Biophysical journal · 2026Review
- Microtubule dependent changes in cell polarity are required for mammary epithelial cell migration and branching morphogenesis.Biology open · 2025Article
- Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation.eLife · 2025Article
- A multicellular star-shaped actin network underpins epithelial organization and connectivity.Nature communications · 2025Article
- Article
- MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation.Journal of cell science · 2022Article
- Vestibular Hair Cells Require CAMSAP3, a Microtubule Minus-End Regulator, for Formation of Normal Kinocilia.Frontiers in cellular neuroscience · 2022Article
- Cyst formation in proximal renal tubules caused by dysfunction of the microtubule minus-end regulator CAMSAP3.Scientific reports · 2021Article
- Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension.Cell stem cell · 2021Article
- Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.Cell death and differentiation · 2021Article
- CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
In most differentiated cells, microtubules reorganize into noncentrosomal arrays that are cell-type specific. In the columnar absorptive enterocytes of the intestine, microtubules form polarized apical-basal arrays that have been proposed to play multiple roles. However, in vivo testing of these hypotheses has been hampered by a lack of genetic tools to specifically perturb microtubules. Here we analyze mice in which microtubules are disrupted by conditional inducible expression of the microtubule-severing protein spastin. Spastin overexpression resulted in multiple cellular defects, including aberrations in nuclear and organelle positioning and deficient nutrient transport. However, cell shape, adhesion, and polarity remained intact, and mutant mice continued to thrive. Notably, the phenotypes of microtubule disruption are similar to those induced by microtubule disorganization upon loss of CAMSAP3/Nezha. These data demonstrate that enterocyte microtubules have important roles in organelle organization but are not essential for growth under homeostatic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.