ArticleJournal of child psychology and psychiatry, and allied disciplines2019
Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.Communications biology · 2021Pooled it
- Soluble urokinase plasminogen activator receptor - What are the clinical potentials in psychiatry?Brain, behavior, & immunity - health · 2026Review
- State educational contexts in childhood and systemic inflammation in later life: Evidence from the health and retirement study.Brain, behavior, & immunity - health · 2026Article
- Executive function and soluble urokinase-type plasminogen activator receptor (suPAR): a longitudinal study of midlife adults.Brain, behavior, and immunity · 2025Article
- Associations between social behaviour and proinflammatory immune activation are modulated by age in a free-ranging primate population.Animal behaviour · 2025Article
- Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Socioeconomic Disadvantage, Neighborhood Belonging, and Inflammation Among Adolescents.Psychosomatic medicine · 2024Article
- The mediating role of child delay of gratification in the link between early and prolonged poverty exposure and adolescent allostatic load.Psychoneuroendocrinology · 2024Article
- Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers: A Life Course Perspective.China CDC weekly · 2024Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms.International journal of molecular sciences · 2024Review
- Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood.Brain, behavior, and immunity · 2024Article
- Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Stage 2 Registered Report: Epigenetic Intergenerational Transmission: Mothers' Adverse Childhood Experiences and DNA Methylation.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort.Schizophrenia bulletin · 2023Article
- Longitudinal links between early adolescent temperament and inflammation among young black adults.Psychoneuroendocrinology · 2023Article
- Discrimination and Inflammation in Adolescents of Color.Biological psychiatry global open science · 2023Article
- Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study.Psychosomatic medicine · 2023Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundChildhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP).
methodsProspective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP).
resultsParticipants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001).
conclusionsExposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.