ArticleJournal of animal science2018
Effects of guanidinoacetic acid on growth performance, creatine and energy metabolism, and carcass characteristics in growing-finishing pigs.
Article in Journal of animal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Guanidinoacetic acid enhances Tibetan sheep-meat quality through the gut-muscle axis: insights from metabolome-microbiome integration.Food chemistry. Molecular sciences · 2026Article
- Enhancement of growth performance, muscle nutrient composition, and nutritional value in rainbow trout (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effect of Amino Acid Derivatives and Polyphenol Supplementation on Ovine Muscle Growth In Vitro and In Vivo.Muscles (Basel, Switzerland) · 2026Article
- Effect of spray-dried porcine plasma and plasma hydrolysate on the health and performance of mycotoxin-challenged piglets at weaning.Tropical animal health and production · 2026Article
- A two-dimensional liquid chromatography method with optimized pretreatment for detection of guanidine compounds in animal liver and kidney.Food chemistry: X · 2025Article
- Optimizing Poultry Growth and Meat Quality: Effects of Guanidinoacetic Acid Supplementation in Yellow-Feathered Broilers.Veterinary sciences · 2025Article
- An indirect competitive ELISA for determination of guanidine acetic acid in animal feed.Scientific reports · 2025Article
- Performance Responses and Fillet Quality of Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
- Effect of Guanidinoacetic Acid on Production Performance, Serum Biochemistry, Meat Quality and Rumen Fermentation in Hu Sheep.Animals : an open access journal from MDPI · 2024Article
- Effect of Guanidinoacetic Acid Supplementation on Growth Performance, Rumen Fermentation, Blood Indices, Nutrient Digestion, and Nitrogen Metabolism in Angus Steers.Animals : an open access journal from MDPI · 2024Article
- Evaluation of guanidinoacetic acid supplementation on finishing beef steer growth performance, skeletal muscle cellular response, and carcass characteristics.Journal of animal science · 2024Article
- Effects of guanidine acetic acid supplementation from gestation to lactation on reproductive performance, colostrum quality, blood biochemistry, and intestinal microflora diversity of sows.Frontiers in veterinary science · 2024Article
- Effects of guanidinoacetic acid supplementation on liver and breast muscle fat deposition, lipid levels, and lipid metabolism-related gene expression in ducks.Frontiers in veterinary science · 2024Article
- Effect of guanidinoacetic acid on the growth performance, myofiber, and adenine nucleotide of meat-type rabbits.Animal bioscience · 2023Article
- Serum Metabolic Characterization of Vitamin E Deficiency inAnimals : an open access journal from MDPI · 2023Article
- Guanidine Acetic Acid Alters Tissue Bound Amino Acid Profiles and Oxidative Status in Finishing Pigs.Animals : an open access journal from MDPI · 2023Article
- Dietary Guanidine Acetic Acid Addition Improved Carcass Quality with Less Back-Fat Thickness and Remarkably Increased Meat Protein Deposition in Rapid-Growing Lambs Fed Different Forage Types.Foods (Basel, Switzerland) · 2023Article
- Dietary guanidinoacetic acid supplementation improves water holding capacity and lowers free amino acid concentration of fresh meat in finishing pigs fed with various dietary protein levels.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Effect of guanidinoacetic acid supplementation on nitrogen retention and methionine methyl group flux in growing steers fed corn-based diets.Journal of animal science · 2022Article
- Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs.Porcine health management · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effects of dietary supplementation with guanidinoacetic acid (GAA) on the growth performance, creatine and energy metabolism, and carcass characteristics in growing-finishing pigs. In Exp. 1, Duroc × Landrace × Yorkshire pigs (n = 180, 33.61 ± 3.91 kg average BW) were blocked by weight and sex, and allotted to 5 treatments with 6 replicates (3 gilts and 3 barrows per replicate pen). Diets were corn-soybean meal-basal diets supplemented with 0, 300, 600, 900, and 1,200 mg/kg of GAA and fed to the pigs for 98 d. From days 1 to 98, G:F increased (linear, P < 0.05) with increasing addition of dietary GAA. Using a broken-line model, the optimum level of dietary GAA was 300 mg/kg during the overall experimental period (days 1 to 98) to maximize G:F. Hot carcass weight, carcass length, and lean percentage showed a tendency to increase (quadratic, 0.05 < P < 0.10) with increasing addition of dietary GAA. On day 98, serum GAA and liver creatine tended to increase (linear, P = 0.10, 0.07) as dietary GAA increased. In addition, serum ATP on day 98 increased linearly (linear, P < 0.01), and muscle ATP and adenosine monophosphate increased quadratically (quadratic, P = 0.05) with incremental GAA supplementation. In Exp. 2, Duroc × Landrace × Yorkshire pigs (n = 180, 53.19 ± 5.63 kg average BW) were blocked by weight and sex, and allotted to 5 treatments with 6 replicates (3 gilts and 3 barrows per replicate pen). Diets were corn-soybean meal-basal diets supplemented with 0, 150, 300, 600, and 1,200 mg/kg of GAA for 35 d. As dietary GAA increased, final BW, ADG, and G:F increased quadratically (quadratic, P < 0.01), and 300 mg/kg of GAA maximized ADG and final BW (P < 0.05).The results indicate that dietary GAA could increase the creatine and ATP load in the tissues of pigs and accordingly improve growth performance. Dietary supplementation with 300 mg/kg of GAA was suitable to maximize the growth performance of growing-finishing pigs.
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