SynthesisHuman molecular genetics2018
A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.
Synthesis in Human molecular genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.Molecular psychiatry · 2022Pooled it
- Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank.Biological psychiatry global open science · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry.Schizophrenia (Heidelberg, Germany) · 2025Article
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- A longitudinal network of psychotic-like experiences, depressive and anxiety symptoms, and adverse life events: a cohort study of 3,358 college students.Epidemiology and psychiatric sciences · 2024Article
- Independent and joint effects of genomic and exposomic loads for schizophrenia on distressing and persisting psychotic experiences in adolescence.medRxiv : the preprint server for health sciences · 2024Article
- Dissecting Schizotypy and Its Association With Cognition and Polygenic Risk for Schizophrenia in a Nonclinical Sample.Schizophrenia bulletin · 2023Article
- Genetic and Geographical Associations With Six Dimensions of Psychotic Experiences in Adolesence.Schizophrenia bulletin · 2023Article
- Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects.Journal of clinical medicine · 2022Article
- Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.PLoS genetics · 2022Article
- The Latent Structure of Negative Symptoms in the General Population in Adolescence and Emerging Adulthood.Schizophrenia bulletin open · 2022Article
- The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.Translational psychiatry · 2021Article
- Psychotic-Like Experiences in Adolescence Occurring in Combination or Isolation: Associations with Schizophrenia Risk Factors.Psychiatric research and clinical practice · 2021Article
- Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.Epidemiology and psychiatric sciences · 2020Article
- The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank.Translational psychiatry · 2020Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders.Translational psychiatry · 2020Article
- Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk.The American journal of psychiatry · 2020Article
- Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present a systematic review of genome-wide research on psychotic experience and negative symptom (PENS) traits in the community. We integrate these new findings, most of which have emerged over the last four years, with more established behaviour genetic and epidemiological research. The review includes the first genome-wide association studies of PENS, including a recent meta-analysis, and the first SNP heritability estimates. Sample sizes of <10 000 participants mean that no genome-wide significant variants have yet been replicated. Importantly, however, in the most recent and well-powered studies, polygenic risk score prediction and linkage disequilibrium (LD) score regression analyses show that all types of PENS share genetic influences with diagnosed schizophrenia and that negative symptom traits also share genetic influences with major depression. These genetic findings corroborate other evidence in supporting a link between PENS in the community and psychiatric conditions. Beyond the systematic review, we highlight recent work on gene-environment correlation, which appears to be a relevant process for psychotic experiences. Genes that influence risk factors such as tobacco use and stressful life events are likely to be harbouring 'hits' that also influence PENS. We argue for the acceptance of PENS within the mainstream, as heritable traits in the same vein as other sub-clinical psychopathology and personality styles such as neuroticism. While acknowledging some mixed findings, new evidence shows genetic overlap between PENS and psychiatric conditions. In sum, normal variations in adolescent and adult thinking styles, such as feeling paranoid, are heritable and show genetic associations with schizophrenia and major depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.